TY - JOUR
T1 - Novel disease resistance specificities result from sequence exchange between tandemly repeated genes at the Cf-4/9 locus of tomato
AU - Parniske, Martin
AU - Hammond-Kosack, Kim E.
AU - Golstein, Catherine
AU - Thomas, Colwyn M.
AU - Jones, David A.
AU - Harrison, Kate
AU - Wulff, Brande B.H.
AU - Jones, Jonathan D.G.
N1 - Generated from Scopus record by KAUST IRTS on 2023-02-20
PY - 1997/12/12
Y1 - 1997/12/12
N2 - Tomato Cf genes confer resistance to C. fulvum, reside in complex loci carrying multiple genes, and encode predicted membrane-bound proteins with extracytoplasmic leucine-rich repeats. At least two Cf-g homologs confer novel C. fulvum resistance specificities. Comparison of 11 genes revealed 7 hypervariable amino acid positions in a motif of the leucine-rich repeats predicted to form a β-strand/β-turn in which the hypervariable residues are solvent exposed and potentially contribute to recognition specificity. Higher nonsynonymous than synonymous substitution rates in this region imply selection for sequence diversification. We propose that the level of polymorphism between intergenic regions determines the frequency of sequence exchange between the tandemly repeated genes. This permits sufficient exchange to generate sequence diversity but prevents sequence homogenization.
AB - Tomato Cf genes confer resistance to C. fulvum, reside in complex loci carrying multiple genes, and encode predicted membrane-bound proteins with extracytoplasmic leucine-rich repeats. At least two Cf-g homologs confer novel C. fulvum resistance specificities. Comparison of 11 genes revealed 7 hypervariable amino acid positions in a motif of the leucine-rich repeats predicted to form a β-strand/β-turn in which the hypervariable residues are solvent exposed and potentially contribute to recognition specificity. Higher nonsynonymous than synonymous substitution rates in this region imply selection for sequence diversification. We propose that the level of polymorphism between intergenic regions determines the frequency of sequence exchange between the tandemly repeated genes. This permits sufficient exchange to generate sequence diversity but prevents sequence homogenization.
UR - https://linkinghub.elsevier.com/retrieve/pii/S0092867400804705
UR - http://www.scopus.com/inward/record.url?scp=0031469143&partnerID=8YFLogxK
U2 - 10.1016/S0092-8674(00)80470-5
DO - 10.1016/S0092-8674(00)80470-5
M3 - Article
SN - 0092-8674
VL - 91
SP - 821
EP - 832
JO - Cell
JF - Cell
IS - 6
ER -