Novel disease resistance specificities result from sequence exchange between tandemly repeated genes at the Cf-4/9 locus of tomato

Martin Parniske, Kim E. Hammond-Kosack, Catherine Golstein, Colwyn M. Thomas, David A. Jones, Kate Harrison, Brande B.H. Wulff, Jonathan D.G. Jones

Research output: Contribution to journalArticlepeer-review

482 Scopus citations

Abstract

Tomato Cf genes confer resistance to C. fulvum, reside in complex loci carrying multiple genes, and encode predicted membrane-bound proteins with extracytoplasmic leucine-rich repeats. At least two Cf-g homologs confer novel C. fulvum resistance specificities. Comparison of 11 genes revealed 7 hypervariable amino acid positions in a motif of the leucine-rich repeats predicted to form a β-strand/β-turn in which the hypervariable residues are solvent exposed and potentially contribute to recognition specificity. Higher nonsynonymous than synonymous substitution rates in this region imply selection for sequence diversification. We propose that the level of polymorphism between intergenic regions determines the frequency of sequence exchange between the tandemly repeated genes. This permits sufficient exchange to generate sequence diversity but prevents sequence homogenization.
Original languageEnglish (US)
Pages (from-to)821-832
Number of pages12
JournalCell
Volume91
Issue number6
DOIs
StatePublished - Dec 12 1997
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-02-20

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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