Novel amperometric glucose biosensor based on MXene nanocomposite

Rakhi Raghavan Baby, Pranati Nayuk, Chuan Xia, Husam N. Alshareef

Research output: Contribution to journalArticlepeer-review

267 Scopus citations


A biosensor platform based on Au/MXene nanocomposite for sensitive enzymatic glucose detection is reported. The biosensor leverages the unique electrocatalytic properties and synergistic effects between Au nanoparticles and MXene sheets. An amperometric glucose biosensor is fabricated by the immobilization of glucose oxidase (GOx) enzyme on Nafion solubilized Au/ MXene nanocomposite over glassy carbon electrode (GCE). The biomediated Au nanoparticles play a significant role in facilitating the electron exchange between the electroactive center of GOx and the electrode. The GOx/Au/MXene/Nafion/GCE biosensor electrode displayed a linear amperometric response in the glucose concentration range from 0.1 to 18 mM with a relatively high sensitivity of 4.2 μAmM−1 cm−2 and a detection limit of 5.9 μM (S/N = 3). Furthermore, the biosensor exhibited excellent stability, reproducibility and repeatability. Therefore, the Au/MXene nanocomposite reported in this work is a potential candidate as an electrochemical transducer in electrochemical biosensors.
Original languageEnglish (US)
JournalScientific Reports
Issue number1
StatePublished - Nov 10 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: Research reported in this manuscript has been supported by King Abdullah University of Science and Technology. Authors thank the ‘Advanced Nanofabrication and Imaging and Characterization Laboratories’ at KAUST. R. B. Rakhi acknowledges the support of Ramanujan Fellowship, Department of Science and Technology (DST), Govt. of India and CSIR-NIIST Thiruvananthapuram, India.


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