TY - CHAP
T1 - Noradrenergic System and Memory
AU - Zenger, Manuel
AU - Burlet-Godinot, Sophie
AU - Petit, Jean-Marie
AU - Magistretti, Pierre J.
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2017/7/22
Y1 - 2017/7/22
N2 - There is ample evidence indicating that noradrenaline plays an important role in memory mechanisms. Noradrenaline is thought to modulate these procsses through activation of adrenergic receptors in neurons. Astrocytes that form essential partners for synaptic function, also express alpha- and beta-adrenergic receptors. In astrocytes, noradrenaline triggers metabolic actions such as the glycogenolysis leading to an increase in l-lactate formation and release. l-Lactate can be used by neurons as a sourc of energy during memory tasks and can also induc transcription of plasticity genes in neurons. Activation of β-adrenergic receptors can also trigger gliotransmitter release resulting of intracllular calcium waves. These gliotransmitters modulate the synaptic activity and thereby can modulate long-term potentiation mechanisms. In summary, recnt evidencs indicate that noradrenaline exerts its memory-promoting effects through different modes of action both on neurons and astrocytes.
AB - There is ample evidence indicating that noradrenaline plays an important role in memory mechanisms. Noradrenaline is thought to modulate these procsses through activation of adrenergic receptors in neurons. Astrocytes that form essential partners for synaptic function, also express alpha- and beta-adrenergic receptors. In astrocytes, noradrenaline triggers metabolic actions such as the glycogenolysis leading to an increase in l-lactate formation and release. l-Lactate can be used by neurons as a sourc of energy during memory tasks and can also induc transcription of plasticity genes in neurons. Activation of β-adrenergic receptors can also trigger gliotransmitter release resulting of intracllular calcium waves. These gliotransmitters modulate the synaptic activity and thereby can modulate long-term potentiation mechanisms. In summary, recnt evidencs indicate that noradrenaline exerts its memory-promoting effects through different modes of action both on neurons and astrocytes.
UR - http://hdl.handle.net/10754/626794
UR - http://www.sciencedirect.com/science/article/pii/B9780128050880000098
UR - http://www.scopus.com/inward/record.url?scp=85032158163&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-805088-0.00009-8
DO - 10.1016/B978-0-12-805088-0.00009-8
M3 - Chapter
AN - SCOPUS:85032158163
SN - 9780128050880
SP - 183
EP - 200
BT - Noradrenergic Signaling and Astroglia
PB - Elsevier BV
ER -