Non-Classical C–H···X Hydrogen Bonding and Its Role in Asymmetric Organocatalysis

Manjaly John Ajitha; Kuo-Wei Huang

doi:10.1055/s-0035-1562475

Non-Classical C–H···X Hydrogen Bonding and Its Role in Asymmetric Organocatalysis

Manjaly John Ajitha, Kuo-Wei Huang

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39 Scopus citations

Abstract

Non-classical hydrogen bonds (NCHBs) have attracted significant interest in the past decade particularly because of their important role in asymmetric catalytic systems. These weak interactions (< 4 kcal/mol) offer much flexibility in the preorganization of molecular entities required to achieve high enantioselectivity. Herein, we review some recent important organocatalytic asymmetric reactions where a NCHB serves as a critical factor in determining the stereoselectivity.

Original language	English (US)
Pages (from-to)	3449-3458
Number of pages	10
Journal	Synthesis
Volume	48
Issue number	20
DOIs	https://doi.org/10.1055/s-0035-1562475
State	Published - Aug 17 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work is supported by King Abdullah University of Science and Technology (KAUST).

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10.1055/s-0035-1562475

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AU - Huang, Kuo-Wei

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AB - Non-classical hydrogen bonds (NCHBs) have attracted significant interest in the past decade particularly because of their important role in asymmetric catalytic systems. These weak interactions (< 4 kcal/mol) offer much flexibility in the preorganization of molecular entities required to achieve high enantioselectivity. Herein, we review some recent important organocatalytic asymmetric reactions where a NCHB serves as a critical factor in determining the stereoselectivity.

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Non-Classical C–H···X Hydrogen Bonding and Its Role in Asymmetric Organocatalysis

Abstract

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