Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

Adarsh Kumar, Ankit Kumar Singh, Harshwardhan Singh, Veena Vijayan, Deepak Kumar, Jashwanth Naik, Suresh Thareja, Jagat Pal Yadav, Prateek Pathak, Maria Grishina, Amita Verma, Habibullah Khalilullah, Mariusz Jaremko, Abdul-Hamid M. Emwas, Pradeep Kumar

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Cancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance. So, there is a dire need to develop safer and target-specific anticancer drugs. More than 85% of all physiologically active pharmaceuticals are heterocycles or contain at least one heteroatom. Nitrogen heterocycles constituting the most common heterocyclic framework. In this study, we have compiled the FDA approved heterocyclic drugs with nitrogen atoms and their pharmacological properties. Moreover, we have reported nitrogen containing heterocycles, including pyrimidine, quinolone, carbazole, pyridine, imidazole, benzimidazole, triazole, β-lactam, indole, pyrazole, quinazoline, quinoxaline, isatin, pyrrolo-benzodiazepines, and pyrido[2,3-d]pyrimidines, which are used in the treatment of different types of cancer, concurrently covering the biochemical mechanisms of action and cellular targets.
Original languageEnglish (US)
Pages (from-to)299
Issue number2
StatePublished - Feb 14 2023

Bibliographical note

KAUST Repository Item: Exported on 2023-02-17
Acknowledgements: The APC was funded by King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah, Saudi Arabia. The authors are thankful to Central University of Punjab and DST-FIST, India and South Ural State University, Russia for providing infrastructural facilities for the successful completion of this study.

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Molecular Medicine


Dive into the research topics of 'Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective'. Together they form a unique fingerprint.

Cite this