Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

Adarsh Kumar; Ankit Kumar Singh; Harshwardhan Singh; Veena Vijayan; Deepak Kumar; Jashwanth Naik; Suresh Thareja; Jagat Pal Yadav; Prateek Pathak; Maria Grishina; Amita Verma; Habibullah Khalilullah; Mariusz Jaremko; Abdul-Hamid M. Emwas; Pradeep Kumar

doi:10.3390/ph16020299

Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

Adarsh Kumar, Ankit Kumar Singh, Harshwardhan Singh, Veena Vijayan, Deepak Kumar, Jashwanth Naik, Suresh Thareja, Jagat Pal Yadav, Prateek Pathak, Maria Grishina, Amita Verma, Habibullah Khalilullah, Mariusz Jaremko, Abdul-Hamid M. Emwas, Pradeep Kumar

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Cancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance. So, there is a dire need to develop safer and target-specific anticancer drugs. More than 85% of all physiologically active pharmaceuticals are heterocycles or contain at least one heteroatom. Nitrogen heterocycles constituting the most common heterocyclic framework. In this study, we have compiled the FDA approved heterocyclic drugs with nitrogen atoms and their pharmacological properties. Moreover, we have reported nitrogen containing heterocycles, including pyrimidine, quinolone, carbazole, pyridine, imidazole, benzimidazole, triazole, β-lactam, indole, pyrazole, quinazoline, quinoxaline, isatin, pyrrolo-benzodiazepines, and pyrido[2,3-d]pyrimidines, which are used in the treatment of different types of cancer, concurrently covering the biochemical mechanisms of action and cellular targets.

Original language	English (US)
Pages (from-to)	299
Journal	Pharmaceuticals
Volume	16
Issue number	2
DOIs	https://doi.org/10.3390/ph16020299
State	Published - Feb 14 2023

Bibliographical note

KAUST Repository Item: Exported on 2023-02-17
Acknowledgements: The APC was funded by King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah, Saudi Arabia. The authors are thankful to Central University of Punjab and DST-FIST, India and South Ural State University, Russia for providing infrastructural facilities for the successful completion of this study.

ASJC Scopus subject areas

Pharmaceutical Science
Molecular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ph16020299

https://repository.kaust.edu.sa/bitstream/10754/687822/1/pharmaceuticals-16-00299%20%281%29.pdf

Cite this

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title = "Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective",

abstract = "Cancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance. So, there is a dire need to develop safer and target-specific anticancer drugs. More than 85% of all physiologically active pharmaceuticals are heterocycles or contain at least one heteroatom. Nitrogen heterocycles constituting the most common heterocyclic framework. In this study, we have compiled the FDA approved heterocyclic drugs with nitrogen atoms and their pharmacological properties. Moreover, we have reported nitrogen containing heterocycles, including pyrimidine, quinolone, carbazole, pyridine, imidazole, benzimidazole, triazole, β-lactam, indole, pyrazole, quinazoline, quinoxaline, isatin, pyrrolo-benzodiazepines, and pyrido[2,3-d]pyrimidines, which are used in the treatment of different types of cancer, concurrently covering the biochemical mechanisms of action and cellular targets.",

author = "Adarsh Kumar and {Kumar Singh}, Ankit and Harshwardhan Singh and Veena Vijayan and Deepak Kumar and Jashwanth Naik and Suresh Thareja and {Pal Yadav}, Jagat and Prateek Pathak and Maria Grishina and Amita Verma and Habibullah Khalilullah and Mariusz Jaremko and Emwas, {Abdul-Hamid M.} and Pradeep Kumar",

note = "KAUST Repository Item: Exported on 2023-02-17 Acknowledgements: The APC was funded by King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah, Saudi Arabia. The authors are thankful to Central University of Punjab and DST-FIST, India and South Ural State University, Russia for providing infrastructural facilities for the successful completion of this study.",

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AU - Kumar, Adarsh

AU - Kumar Singh, Ankit

AU - Singh, Harshwardhan

AU - Vijayan, Veena

AU - Kumar, Deepak

AU - Naik, Jashwanth

AU - Thareja, Suresh

AU - Pal Yadav, Jagat

AU - Pathak, Prateek

AU - Grishina, Maria

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AU - Khalilullah, Habibullah

AU - Jaremko, Mariusz

AU - Emwas, Abdul-Hamid M.

AU - Kumar, Pradeep

N1 - KAUST Repository Item: Exported on 2023-02-17 Acknowledgements: The APC was funded by King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah, Saudi Arabia. The authors are thankful to Central University of Punjab and DST-FIST, India and South Ural State University, Russia for providing infrastructural facilities for the successful completion of this study.

PY - 2023/2/14

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N2 - Cancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance. So, there is a dire need to develop safer and target-specific anticancer drugs. More than 85% of all physiologically active pharmaceuticals are heterocycles or contain at least one heteroatom. Nitrogen heterocycles constituting the most common heterocyclic framework. In this study, we have compiled the FDA approved heterocyclic drugs with nitrogen atoms and their pharmacological properties. Moreover, we have reported nitrogen containing heterocycles, including pyrimidine, quinolone, carbazole, pyridine, imidazole, benzimidazole, triazole, β-lactam, indole, pyrazole, quinazoline, quinoxaline, isatin, pyrrolo-benzodiazepines, and pyrido[2,3-d]pyrimidines, which are used in the treatment of different types of cancer, concurrently covering the biochemical mechanisms of action and cellular targets.

AB - Cancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance. So, there is a dire need to develop safer and target-specific anticancer drugs. More than 85% of all physiologically active pharmaceuticals are heterocycles or contain at least one heteroatom. Nitrogen heterocycles constituting the most common heterocyclic framework. In this study, we have compiled the FDA approved heterocyclic drugs with nitrogen atoms and their pharmacological properties. Moreover, we have reported nitrogen containing heterocycles, including pyrimidine, quinolone, carbazole, pyridine, imidazole, benzimidazole, triazole, β-lactam, indole, pyrazole, quinazoline, quinoxaline, isatin, pyrrolo-benzodiazepines, and pyrido[2,3-d]pyrimidines, which are used in the treatment of different types of cancer, concurrently covering the biochemical mechanisms of action and cellular targets.

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Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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