Nickel-Catalyzed Csp2–Csp3 Bond Formation via C–F Bond Activation

Yee Ann Ho, Matthias Leiendecker, Xiangqian Liu, Chengming Wang, Nurtalya Alandini, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


A nickel-catalyzed cross coupling of aryl fluorides via C–F bond activation has been developed. The alkylation method allows selective replacement of aryl fluorides by alkyl groups and enables the synthesis of diverse and otherwise difficult to access scaffolds in good yields.
Original languageEnglish (US)
Pages (from-to)5644-5647
Number of pages4
JournalOrganic Letters
Issue number18
StatePublished - Aug 31 2018

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: Y.A.H. acknowledges the DAAD for a scholarship. M.L. was supported by a Kekulé fellowship (Fonds der Chemischen Industrie) and the Studienstiftung des Deutschen Volkes.


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