Nickel-Catalyzed C–CN Bond Formation via Decarbonylative Cyanation of Esters, Amides, and Intramolecular Recombination Fragment Coupling of Acyl Cyanides

Adisak Chatupheeraphat, Hsuan-Hung Liao, Shao-Chi Lee, Magnus Rueping

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An efficient nickel-catalyzed decarbonylative cyanation reaction which allows the direct functional-group interconversion of readily available esters into the corresponding nitriles was developed. This reaction successfully offers access to structurally diverse nitriles with high efficiency and excellent functional-group tolerance and provides a good alternative to classical synthetic pathways from diazonium salts or organic halide compounds.
Original languageEnglish (US)
Pages (from-to)4255-4258
Number of pages4
JournalOrganic Letters
Issue number16
StatePublished - Aug 7 2017

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