Niche-less maintenance of HSCs by 2i

Shigeo Masuda; Mo Li; Juan Carlos Izpisua Belmonte

doi:10.1038/cr.2013.14

Niche-less maintenance of HSCs by 2i

Shigeo Masuda, Mo Li, Juan Carlos Izpisua Belmonte^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Maintenance of hematopoietic stem cells (HSCs) in vitro has been believed to be difficult due to a lack of complete understanding of HSC quiescence maintained by the niche. Recent evidence suggests that in vitro maintenance of human and mouse long-term HSCs (LT-HSCs) is possible through dual inhibition (2i) of both GSK-3 and mTOR in the absence of cytokines, serum, or feeder cells.

Original language	English (US)
Pages (from-to)	458-459
Number of pages	2
Journal	Cell research
Volume	23
Issue number	4
DOIs	https://doi.org/10.1038/cr.2013.14
State	Published - Apr 2013
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/cr.2013.14

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title = "Niche-less maintenance of HSCs by 2i",

abstract = "Maintenance of hematopoietic stem cells (HSCs) in vitro has been believed to be difficult due to a lack of complete understanding of HSC quiescence maintained by the niche. Recent evidence suggests that in vitro maintenance of human and mouse long-term HSCs (LT-HSCs) is possible through dual inhibition (2i) of both GSK-3 and mTOR in the absence of cytokines, serum, or feeder cells.",

author = "Shigeo Masuda and Mo Li and Belmonte, {Juan Carlos Izpisua}",

year = "2013",

month = apr,

doi = "10.1038/cr.2013.14",

language = "English (US)",

volume = "23",

pages = "458--459",

journal = "Cell research",

issn = "1001-0602",

publisher = "Springer Nature",

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T1 - Niche-less maintenance of HSCs by 2i

AU - Masuda, Shigeo

AU - Li, Mo

AU - Belmonte, Juan Carlos Izpisua

PY - 2013/4

Y1 - 2013/4

N2 - Maintenance of hematopoietic stem cells (HSCs) in vitro has been believed to be difficult due to a lack of complete understanding of HSC quiescence maintained by the niche. Recent evidence suggests that in vitro maintenance of human and mouse long-term HSCs (LT-HSCs) is possible through dual inhibition (2i) of both GSK-3 and mTOR in the absence of cytokines, serum, or feeder cells.

AB - Maintenance of hematopoietic stem cells (HSCs) in vitro has been believed to be difficult due to a lack of complete understanding of HSC quiescence maintained by the niche. Recent evidence suggests that in vitro maintenance of human and mouse long-term HSCs (LT-HSCs) is possible through dual inhibition (2i) of both GSK-3 and mTOR in the absence of cytokines, serum, or feeder cells.

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U2 - 10.1038/cr.2013.14

DO - 10.1038/cr.2013.14

M3 - Article

C2 - 23357848

AN - SCOPUS:84876411506

SN - 1001-0602

VL - 23

SP - 458

EP - 459

JO - Cell research

JF - Cell research

IS - 4

ER -

Niche-less maintenance of HSCs by 2i

Abstract

ASJC Scopus subject areas

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