NFIX - One gene, two knockouts, multiple effects

Vladimir Pekarik; Juan Carlos Izpisua Belmonte

doi:10.1186/jbiol94

NFIX - One gene, two knockouts, multiple effects

Vladimir Pekarik, Juan Carlos Izpisua Belmonte

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.

Original language	English (US)
Article number	29
Journal	Journal of Biology
Volume	7
Issue number	8
DOIs	https://doi.org/10.1186/jbiol94
State	Published - 2008
Externally published	Yes

Bibliographical note

Funding Information:
Work in the laboratory of Juan Carlos Izpisua Belmonte was supported by funds from the G Harold and Leila Y Mathers Charitable Foundation, Fundacion Cellex and the Marato.

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1186/jbiol94

Cite this

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title = "NFIX - One gene, two knockouts, multiple effects",

abstract = "A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.",

author = "Vladimir Pekarik and Belmonte, {Juan Carlos Izpisua}",

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AU - Belmonte, Juan Carlos Izpisua

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AB - A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.

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U2 - 10.1186/jbiol94

DO - 10.1186/jbiol94

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JO - Journal of Biology

JF - Journal of Biology

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ER -

NFIX - One gene, two knockouts, multiple effects

Abstract

Bibliographical note

ASJC Scopus subject areas

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