A previous knockout of the transcription factor gene nuclear factor IX (NFIX) in mice produced impaired development of the corpus callosum and severe skeletal defects. A recent paper in BMC Developmental Biology reports an apparently similar NFIX knockout that produced marked differences in phenotype, raising intriguing general questions about the possible causes of such differences in mouse knockouts.
|Original language||English (US)|
|Journal||Journal of Biology|
|State||Published - 2008|
Bibliographical noteFunding Information:
Work in the laboratory of Juan Carlos Izpisua Belmonte was supported by funds from the G Harold and Leila Y Mathers Charitable Foundation, Fundacion Cellex and the Marato.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)