New encouraging developments in contact prediction: Assessment of the CASP11 results

Bohdan Monastyrskyy, Daniel D'Andrea, Krzysztof Fidelis, Anna Tramontano, Andriy Kryshtafovych

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


© 2015 Wiley Periodicals, Inc. This article provides a report on the state-of-the-art in the prediction of intra-molecular residue-residue contacts in proteins based on the assessment of the predictions submitted to the CASP11 experiment. The assessment emphasis is placed on the accuracy in predicting long-range contacts. Twenty-nine groups participated in contact prediction in CASP11. At least eight of them used the recently developed evolutionary coupling techniques, with the top group (CONSIP2) reaching precision of 27% on target proteins that could not be modeled by homology. This result indicates a breakthrough in the development of methods based on the correlated mutation approach. Successful prediction of contacts was shown to be practically helpful in modeling three-dimensional structures; in particular target T0806 was modeled exceedingly well with accuracy not yet seen for ab initio targets of this size (>250 residues).
Original languageEnglish (US)
Pages (from-to)131-144
Number of pages14
JournalProteins: Structure, Function, and Bioinformatics
StatePublished - Nov 17 2015
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUK-I1-012-43
Acknowledgements: Grant sponsor: US National Institute of General Medical Sciences (NIGMS/NIH);Grant number: R01GM100482; Grant sponsor: KAUST Award; Grant number:KUK-I1-012-43.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.


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