New CSPs based on peptidomimetics: Efficient chiral selectors in enantioselective separations

M. Isabel Burguete; Jean M.J. Fréchet; Eduardo García-Verdugo; Miroslav Janco; Santiago V. Luis; Frantisek Svec; María J. Vicent; Mingcheng Xu

doi:10.1007/s00289-002-0005-3

New CSPs based on peptidomimetics: Efficient chiral selectors in enantioselective separations

M. Isabel Burguete, Jean M.J. Fréchet, Eduardo García-Verdugo, Miroslav Janco, Santiago V. Luis^*, Frantisek Svec, María J. Vicent, Mingcheng Xu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Two different families of peptidomimetics have been synthesized and used as chiral selectors for enantioselective chromatography. The functionalization of compounds with multiple nitrogen atoms allows their use in the preparation of chiral stationary phases (CSPs), with acrylic or styril comonomers, in both bead and monolithic formats. Some of these separation media, having the appropriate morphological properties for their use in chromatographic columns, were able to efficiently discriminate enantiomers of aminoacid derivatives and pharmaceuticals such as Oxazepam.

Original language	English (US)
Pages (from-to)	9-15
Number of pages	7
Journal	Polymer Bulletin
Volume	48
Issue number	1
DOIs	https://doi.org/10.1007/s00289-002-0005-3
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
Condensed Matter Physics
Polymers and Plastics
Materials Chemistry

Access to Document

10.1007/s00289-002-0005-3

Cite this

@article{72154df6b255424087cc589b3fdd3448,

title = "New CSPs based on peptidomimetics: Efficient chiral selectors in enantioselective separations",

abstract = "Two different families of peptidomimetics have been synthesized and used as chiral selectors for enantioselective chromatography. The functionalization of compounds with multiple nitrogen atoms allows their use in the preparation of chiral stationary phases (CSPs), with acrylic or styril comonomers, in both bead and monolithic formats. Some of these separation media, having the appropriate morphological properties for their use in chromatographic columns, were able to efficiently discriminate enantiomers of aminoacid derivatives and pharmaceuticals such as Oxazepam.",

author = "Burguete, {M. Isabel} and Fr{\'e}chet, {Jean M.J.} and Eduardo Garc{\'i}a-Verdugo and Miroslav Janco and Luis, {Santiago V.} and Frantisek Svec and Vicent, {Mar{\'i}a J.} and Mingcheng Xu",

year = "2002",

doi = "10.1007/s00289-002-0005-3",

language = "English (US)",

volume = "48",

pages = "9--15",

journal = "Polymer Bulletin",

issn = "0170-0839",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - New CSPs based on peptidomimetics

T2 - Efficient chiral selectors in enantioselective separations

AU - Burguete, M. Isabel

AU - Fréchet, Jean M.J.

AU - García-Verdugo, Eduardo

AU - Janco, Miroslav

AU - Luis, Santiago V.

AU - Svec, Frantisek

AU - Vicent, María J.

AU - Xu, Mingcheng

PY - 2002

Y1 - 2002

N2 - Two different families of peptidomimetics have been synthesized and used as chiral selectors for enantioselective chromatography. The functionalization of compounds with multiple nitrogen atoms allows their use in the preparation of chiral stationary phases (CSPs), with acrylic or styril comonomers, in both bead and monolithic formats. Some of these separation media, having the appropriate morphological properties for their use in chromatographic columns, were able to efficiently discriminate enantiomers of aminoacid derivatives and pharmaceuticals such as Oxazepam.

AB - Two different families of peptidomimetics have been synthesized and used as chiral selectors for enantioselective chromatography. The functionalization of compounds with multiple nitrogen atoms allows their use in the preparation of chiral stationary phases (CSPs), with acrylic or styril comonomers, in both bead and monolithic formats. Some of these separation media, having the appropriate morphological properties for their use in chromatographic columns, were able to efficiently discriminate enantiomers of aminoacid derivatives and pharmaceuticals such as Oxazepam.

UR - http://www.scopus.com/inward/record.url?scp=0036933298&partnerID=8YFLogxK

U2 - 10.1007/s00289-002-0005-3

DO - 10.1007/s00289-002-0005-3

M3 - Article

AN - SCOPUS:0036933298

SN - 0170-0839

VL - 48

SP - 9

EP - 15

JO - Polymer Bulletin

JF - Polymer Bulletin

IS - 1

ER -

New CSPs based on peptidomimetics: Efficient chiral selectors in enantioselective separations

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this