New CSPs based on peptidomimetics: Efficient chiral selectors in enantioselective separations

M. Isabel Burguete; Jean Frechet; Eduardo García-Verdugo; Miroslav Janco; Santiago V. Luis; Frantisek Svec; María J. Vicent; Mingcheng Xu

doi:10.1007/s00289-002-0005-3

New CSPs based on peptidomimetics: Efficient chiral selectors in enantioselective separations

M. Isabel Burguete, Jean Frechet, Eduardo García-Verdugo, Miroslav Janco, Santiago V. Luis^*, Frantisek Svec, María J. Vicent, Mingcheng Xu

^*Corresponding author for this work

Physical Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Two different families of peptidomimetics have been synthesized and used as chiral selectors for enantioselective chromatography. The functionalization of compounds with multiple nitrogen atoms allows their use in the preparation of chiral stationary phases (CSPs), with acrylic or styril comonomers, in both bead and monolithic formats. Some of these separation media, having the appropriate morphological properties for their use in chromatographic columns, were able to efficiently discriminate enantiomers of aminoacid derivatives and pharmaceuticals such as Oxazepam.

Original language	English (US)
Pages (from-to)	9-15
Number of pages	7
Journal	Polymer Bulletin
Volume	48
Issue number	1
DOIs	https://doi.org/10.1007/s00289-002-0005-3
State	Published - Dec 1 2002

ASJC Scopus subject areas

Chemistry(all)
Condensed Matter Physics
Polymers and Plastics
Materials Chemistry

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abstract = "Two different families of peptidomimetics have been synthesized and used as chiral selectors for enantioselective chromatography. The functionalization of compounds with multiple nitrogen atoms allows their use in the preparation of chiral stationary phases (CSPs), with acrylic or styril comonomers, in both bead and monolithic formats. Some of these separation media, having the appropriate morphological properties for their use in chromatographic columns, were able to efficiently discriminate enantiomers of aminoacid derivatives and pharmaceuticals such as Oxazepam.",

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T1 - New CSPs based on peptidomimetics

T2 - Efficient chiral selectors in enantioselective separations

AU - Burguete, M. Isabel

AU - Frechet, Jean

AU - García-Verdugo, Eduardo

AU - Janco, Miroslav

AU - Luis, Santiago V.

AU - Svec, Frantisek

AU - Vicent, María J.

AU - Xu, Mingcheng

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Two different families of peptidomimetics have been synthesized and used as chiral selectors for enantioselective chromatography. The functionalization of compounds with multiple nitrogen atoms allows their use in the preparation of chiral stationary phases (CSPs), with acrylic or styril comonomers, in both bead and monolithic formats. Some of these separation media, having the appropriate morphological properties for their use in chromatographic columns, were able to efficiently discriminate enantiomers of aminoacid derivatives and pharmaceuticals such as Oxazepam.

AB - Two different families of peptidomimetics have been synthesized and used as chiral selectors for enantioselective chromatography. The functionalization of compounds with multiple nitrogen atoms allows their use in the preparation of chiral stationary phases (CSPs), with acrylic or styril comonomers, in both bead and monolithic formats. Some of these separation media, having the appropriate morphological properties for their use in chromatographic columns, were able to efficiently discriminate enantiomers of aminoacid derivatives and pharmaceuticals such as Oxazepam.

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U2 - 10.1007/s00289-002-0005-3

DO - 10.1007/s00289-002-0005-3

M3 - Article

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SP - 9

EP - 15

JO - Polymer Bulletin

JF - Polymer Bulletin

IS - 1

ER -

New CSPs based on peptidomimetics: Efficient chiral selectors in enantioselective separations

Abstract

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