New Advances in Fast Methods of 2D NMR Experiments

Abdul-Hamid M. Emwas, Mawadda Alghrably, Samah Al-Harthi, Benjamin Gabriel Poulson, Kacper Szczepski, Kousik Chandra, Mariusz Jaremko

Research output: Chapter in Book/Report/Conference proceedingChapter


Although nuclear magnetic resonance spectroscopy is a potent analytical tool for identification, quantification, and structural elucidation, it suffers from inherently low sensitivity limitations. This chapter focuses on recently reported methods that enable quick acquisition of NMR spectra, as well as new methods of faster, efficient, and informative two-dimensional (2D) NMR methods. Fast and efficient data acquisition has risen in response to an increasing need to investigate chemical and biological processes in real time. Several new techniques have been successfully introduced. One example of this is band-selective optimized-flip-angle short-transient (SOFAST) NMR, which has opened the door to studying the kinetics of biological processes such as the phosphorylation of proteins. The fast recording of NMR spectra allows researchers to investigate time sensitive molecules that have limited stability under experimental conditions. The increasing awareness that molecular structures are dynamic, rather than static, has pushed some researchers to find alternatives to standard, time-consuming methods of 15N relaxation observables acquisition.
Original languageEnglish (US)
Title of host publicationNuclear Magnetic Resonance [Working Title]
StatePublished - Dec 13 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We would like to thank King Abdullah University of Science and Technology for financial support.


Dive into the research topics of 'New Advances in Fast Methods of 2D NMR Experiments'. Together they form a unique fingerprint.

Cite this