Neuroenergetics: Calling upon Astrocytes to Satisfy Hungry Neurons

Luc Pellerin*, Pierre J. Magistretti

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

229 Scopus citations


Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and its full oxidation provides all the necessary energy to support brain function. Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity.

Original languageEnglish (US)
Pages (from-to)53-62
Number of pages10
Issue number1
StatePublished - Feb 2004
Externally publishedYes


  • Aerobic glycolysis
  • Brain energy metabolism
  • Glucose
  • Lactate
  • Monocarboxylate transporters

ASJC Scopus subject areas

  • Clinical Neurology
  • General Neuroscience


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