Neuroenergetics: Calling upon Astrocytes to Satisfy Hungry Neurons

Luc Pellerin; Pierre J. Magistretti

doi:10.1177/1073858403260159

Neuroenergetics: Calling upon Astrocytes to Satisfy Hungry Neurons

Luc Pellerin^*, Pierre J. Magistretti

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

229 Scopus citations

Abstract

Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and its full oxidation provides all the necessary energy to support brain function. Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity.

Original language	English (US)
Pages (from-to)	53-62
Number of pages	10
Journal	Neuroscientist
Volume	10
Issue number	1
DOIs	https://doi.org/10.1177/1073858403260159
State	Published - Feb 2004
Externally published	Yes

Keywords

Aerobic glycolysis
Brain energy metabolism
Glucose
Lactate
Monocarboxylate transporters

ASJC Scopus subject areas

Clinical Neurology
General Neuroscience

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10.1177/1073858403260159

Cite this

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title = "Neuroenergetics: Calling upon Astrocytes to Satisfy Hungry Neurons",

abstract = "Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and its full oxidation provides all the necessary energy to support brain function. Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity.",

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author = "Luc Pellerin and Magistretti, {Pierre J.}",

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AU - Magistretti, Pierre J.

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AB - Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and its full oxidation provides all the necessary energy to support brain function. Recent data have revealed a more intricate picture in which astrocytes play a key role in supplying lactate as an additional energy substrate in register with glutamatergic activity.

KW - Aerobic glycolysis

KW - Brain energy metabolism

KW - Glucose

KW - Lactate

KW - Monocarboxylate transporters

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Neuroenergetics: Calling upon Astrocytes to Satisfy Hungry Neurons

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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