Neuroenergetic Response to Prolonged Cerebral Glucose Depletion after Severe Brain Injury and the Role of Lactate

Camille Patet, Herve Quintard, Tamarah Suys, Jocelyne Bloch, Roy T. Daniel, Luc Pellerin, Pierre J. Magistretti, Mauro Oddo

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Abstract

Lactate may represent a supplemental fuel for the brain. We examined cerebral lactate metabolism during prolonged brain glucose depletion (GD) in acute brain injury (ABI) patients monitored with cerebral microdialysis (CMD). Sixty episodes of GD (defined as spontaneous decreases of CMD glucose from normal to low [
Original languageEnglish (US)
Pages (from-to)1560-1566
Number of pages7
JournalJournal of Neurotrauma
Volume32
Issue number20
DOIs
StatePublished - 2015

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