TY - JOUR
T1 - Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases
AU - Dhahri, Manel
AU - Alghrably, Mawadda
AU - Mohammed, Hamdoon A.
AU - Badshah, Syed Lal
AU - Noreen, Noreen
AU - Mouffouk, Fouzi
AU - Rayyan, Saleh
AU - Qureshi, Kamal A.
AU - Mahmood, Danish
AU - Lachowicz, Joanna Izabela
AU - Jaremko, Mariusz
AU - Emwas, AbdulHamid
N1 - KAUST Repository Item: Exported on 2021-12-22
PY - 2022
Y1 - 2022
N2 - Neurodegenerative diseases are a serious and widespread global public health burden
amongst aging populations. The total estimated worldwide global cost of dementia was US$818
billion in 2015 and has been projected to rise to 2 trillion US$ by 2030. While advances have been
made to understand different neurodegenerative disease mechanisms, effective therapeutic strategies
do not generally exist. Several drugs have been proposed in the last two decades for the treatment
of different types of neurodegenerative diseases, with little therapeutic benefit, and often with
severe adverse and side effects. Thus, the search for novel drugs with higher efficacy and fewer
drawbacks is an ongoing challenge in the treatment of neurodegenerative disease. Several natural
compounds including polysaccharides have demonstrated neuroprotective and even therapeutic
effects. Natural polysaccharides are widely distributed in plants, animals, algae, bacterial and
fungal species, and have received considerable attention for their wide-ranging bioactivity, including
their antioxidant, anti-neuroinflammatory, anticholinesterase and anti-amyloidogenic effects. In
this review, we summarize different mechanisms involved in neurodegenerative diseases and the
neuroprotective effects of natural polysacch
AB - Neurodegenerative diseases are a serious and widespread global public health burden
amongst aging populations. The total estimated worldwide global cost of dementia was US$818
billion in 2015 and has been projected to rise to 2 trillion US$ by 2030. While advances have been
made to understand different neurodegenerative disease mechanisms, effective therapeutic strategies
do not generally exist. Several drugs have been proposed in the last two decades for the treatment
of different types of neurodegenerative diseases, with little therapeutic benefit, and often with
severe adverse and side effects. Thus, the search for novel drugs with higher efficacy and fewer
drawbacks is an ongoing challenge in the treatment of neurodegenerative disease. Several natural
compounds including polysaccharides have demonstrated neuroprotective and even therapeutic
effects. Natural polysaccharides are widely distributed in plants, animals, algae, bacterial and
fungal species, and have received considerable attention for their wide-ranging bioactivity, including
their antioxidant, anti-neuroinflammatory, anticholinesterase and anti-amyloidogenic effects. In
this review, we summarize different mechanisms involved in neurodegenerative diseases and the
neuroprotective effects of natural polysacch
UR - http://hdl.handle.net/10754/674134
UR - https://www.mdpi.com/1999-4923/14/1/1
U2 - 10.3390/pharmaceutics14010001
DO - 10.3390/pharmaceutics14010001
M3 - Article
C2 - 35056897
SN - 1999-4923
VL - 14
SP - 1
JO - Pharmaceutics
JF - Pharmaceutics
IS - 1
ER -
