Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans

S. De Azevedo, M. F. González, C. Cintas, V. Ramallo, M. Quinto-Sánchez, F. Márquez, T. Hünemeier, C. Paschetta, A. Ruderman, P. Navarro, B. A. Pazos, C. C. Silva de Cerqueira, O. Velan, F. Ramírez-Rozzi, N. Calvo, H. G. Castro, R. R. Paz*, R. González-José

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Both modern humans (MHs) and Neanderthals successfully settled across western Eurasian cold-climate landscapes. Among the many adaptations considered as essential to survival in such landscapes, changes in the nasal morphology and/or function aimed to humidify and warm the air before it reaches the lungs are of key importance. Unfortunately, the lack of soft-tissue evidence in the fossil record turns difficult any comparative study of respiratory performance. Here, we reconstruct the internal nasal cavity of a Neanderthal plus two representatives of climatically divergent MH populations (southwestern Europeans and northeastern Asians). The reconstruction includes mucosa distribution enabling a realistic simulation of the breathing cycle in different climatic conditions via computational fluid dynamics. Striking across-specimens differences in fluid residence times affecting humidification and warming performance at the anterior tract were found under cold/dry climate simulations. Specifically, the Asian model achieves a rapid air conditioning, followed by the Neanderthals, whereas the European model attains a proper conditioning only around the medium-posterior tract. In addition, quantitative-genetic evolutionary analyses of nasal morphology provided signals of stabilizing selection for MH populations, with the removal of Arctic populations turning covariation patterns compatible with evolution by genetic drift. Both results indicate that, departing from important craniofacial differences existing among Neanderthals and MHs, an advantageous species-specific respiratory performance in cold climates may have occurred in both species. Fluid dynamics and evolutionary biology independently provided evidence of nasal evolution, suggesting that adaptive explanations regarding complex functional phenotypes require interdisciplinary approaches aimed to quantify both performance and evolutionary signals on covariation patterns.

Original languageEnglish (US)
Pages (from-to)12442-12447
Number of pages6
JournalPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume114
Issue number47
DOIs
StatePublished - Nov 21 2017

Bibliographical note

Funding Information:
aInstituto Patagónico de Ciencias Sociales y Humanas, Centro Nacional Patagónico, Consejo Nacional de Investigaciones Científicas y Técnicas, U9120ACD, Puerto Madryn, Argentina; bCiencia Forense, Facultad de Medicina, Circuito de la Investigación Científica s/n, Ciudad Universitaria, Universidad Nacional Autónoma de México, Del. Coyoacán, CP 04510, Mexico; cInstituto de Biología de Organismos Marinos, Centro Nacional Patagónico, Consejo Nacional de Investigaciones Científicas y Técnicas, U9120ACD, Puerto Madryn, Argentina; dDepartamento de Genética e Biologia Evolutiva, Cidade Universitária, University of São Paulo, 05508-900, São Paulo, Brazil; eSuperintendência da Polícia Técnico-Científica do Estado de São Paulo, Equipe de Perícias Criminalísticas de Ourinhos, 19901-560, São Paulo, Brazil; fDepartamento Académico de Ciencias Morfológicas, Hospital Italiano, C1199ABB, Buenos Aires, Argentina; gUMR 5288 Anthropologie Moléculaire et Imagerie de Synthèse, CNRS, 92120 Montrouge, France; hDepartment of Computing, Universidad Nacional del Litoral, S3000, Santa Fe, Argentina; iInstituto de Modelado e Innovación Tecnológica, Universidad Nacional del Nordeste, CP W3404AAS, Corrientes, Argentina; jConsejo Nacional de Investigaciones Científicas y Técnicas, C1425FQB, Buenos Aires, Argentina; and kLivermore Software Technology Corporation, Livermore, CA 94551

Publisher Copyright:
© 2017, National Academy of Sciences. All rights reserved.

Keywords

  • Computational fluid dynamics
  • Homo sapiens
  • Nasal morphology
  • Neanderthal
  • Quantitative genetics

ASJC Scopus subject areas

  • General

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