"nanohybrids" based on pH-responsive hydrogels and inorganic nanoparticles for drug delivery and sensor applications

Andreas Riedinger; Manuel Pernia Leal; Smriti R. Deka; Chandramohan George; Isabella R. Franchini; Andrea Falqui; Roberto Cingolani; Teresa Pellegrino

doi:10.1021/nl2011627

"nanohybrids" based on pH-responsive hydrogels and inorganic nanoparticles for drug delivery and sensor applications

Andreas Riedinger, Manuel Pernia Leal, Smriti R. Deka, Chandramohan George, Isabella R. Franchini, Andrea Falqui, Roberto Cingolani, Teresa Pellegrino^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Allyl-PEG capped inorganic NPs, including magnetic iron oxide (IONPs), fluorescent CdSe/ZnS quantum dots (QDs), and metallic gold (AuNPs of 5 and 10 nm) both individually and in combination, were covalently attached to pH-responsive poly(2-vinylpyridine-co-divinylbenzene) nanogels via a facile and robust one-step surfactant-free emulsion polymerization procedure. Control of the NPs associated to the nanogels was achieved by the late injection of the NPs to the polymerization solution at a stage when just polymeric radicals were present. Remarkably, by varying the total amount of NPs injected, the swelling behavior could be affected. Furthermore, the magnetic response as well as the optical features of the nanogels containing either IONPs or QDs could be modified. In addition, a radical quenching in case of gold nanoparticles was observed, thus affecting the final nanogel geometry.

Original language	English (US)
Pages (from-to)	3136-3141
Number of pages	6
Journal	Nano Letters
Volume	11
Issue number	8
DOIs	https://doi.org/10.1021/nl2011627
State	Published - Aug 10 2011
Externally published	Yes

Keywords

divinylbenzene
gold nanoparticles
pH responsive hydrogels
quantum dots
superparamagnetic nanoparticles
surfactant freeemulsion polymerization
vinylpyridine

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl2011627

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title = "{"}nanohybrids{"} based on pH-responsive hydrogels and inorganic nanoparticles for drug delivery and sensor applications",

abstract = "Allyl-PEG capped inorganic NPs, including magnetic iron oxide (IONPs), fluorescent CdSe/ZnS quantum dots (QDs), and metallic gold (AuNPs of 5 and 10 nm) both individually and in combination, were covalently attached to pH-responsive poly(2-vinylpyridine-co-divinylbenzene) nanogels via a facile and robust one-step surfactant-free emulsion polymerization procedure. Control of the NPs associated to the nanogels was achieved by the late injection of the NPs to the polymerization solution at a stage when just polymeric radicals were present. Remarkably, by varying the total amount of NPs injected, the swelling behavior could be affected. Furthermore, the magnetic response as well as the optical features of the nanogels containing either IONPs or QDs could be modified. In addition, a radical quenching in case of gold nanoparticles was observed, thus affecting the final nanogel geometry.",

keywords = "divinylbenzene, gold nanoparticles, pH responsive hydrogels, quantum dots, superparamagnetic nanoparticles, surfactant freeemulsion polymerization, vinylpyridine",

author = "Andreas Riedinger and {Pernia Leal}, Manuel and Deka, {Smriti R.} and Chandramohan George and Franchini, {Isabella R.} and Andrea Falqui and Roberto Cingolani and Teresa Pellegrino",

year = "2011",

month = aug,

day = "10",

doi = "10.1021/nl2011627",

language = "English (US)",

volume = "11",

pages = "3136--3141",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

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T1 - "nanohybrids" based on pH-responsive hydrogels and inorganic nanoparticles for drug delivery and sensor applications

AU - Riedinger, Andreas

AU - Pernia Leal, Manuel

AU - Deka, Smriti R.

AU - George, Chandramohan

AU - Franchini, Isabella R.

AU - Falqui, Andrea

AU - Cingolani, Roberto

AU - Pellegrino, Teresa

PY - 2011/8/10

Y1 - 2011/8/10

N2 - Allyl-PEG capped inorganic NPs, including magnetic iron oxide (IONPs), fluorescent CdSe/ZnS quantum dots (QDs), and metallic gold (AuNPs of 5 and 10 nm) both individually and in combination, were covalently attached to pH-responsive poly(2-vinylpyridine-co-divinylbenzene) nanogels via a facile and robust one-step surfactant-free emulsion polymerization procedure. Control of the NPs associated to the nanogels was achieved by the late injection of the NPs to the polymerization solution at a stage when just polymeric radicals were present. Remarkably, by varying the total amount of NPs injected, the swelling behavior could be affected. Furthermore, the magnetic response as well as the optical features of the nanogels containing either IONPs or QDs could be modified. In addition, a radical quenching in case of gold nanoparticles was observed, thus affecting the final nanogel geometry.

AB - Allyl-PEG capped inorganic NPs, including magnetic iron oxide (IONPs), fluorescent CdSe/ZnS quantum dots (QDs), and metallic gold (AuNPs of 5 and 10 nm) both individually and in combination, were covalently attached to pH-responsive poly(2-vinylpyridine-co-divinylbenzene) nanogels via a facile and robust one-step surfactant-free emulsion polymerization procedure. Control of the NPs associated to the nanogels was achieved by the late injection of the NPs to the polymerization solution at a stage when just polymeric radicals were present. Remarkably, by varying the total amount of NPs injected, the swelling behavior could be affected. Furthermore, the magnetic response as well as the optical features of the nanogels containing either IONPs or QDs could be modified. In addition, a radical quenching in case of gold nanoparticles was observed, thus affecting the final nanogel geometry.

KW - divinylbenzene

KW - gold nanoparticles

KW - pH responsive hydrogels

KW - quantum dots

KW - superparamagnetic nanoparticles

KW - surfactant freeemulsion polymerization

KW - vinylpyridine

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DO - 10.1021/nl2011627

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SN - 1530-6984

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SP - 3136

EP - 3141

JO - Nano Letters

JF - Nano Letters

IS - 8

ER -

"nanohybrids" based on pH-responsive hydrogels and inorganic nanoparticles for drug delivery and sensor applications

Abstract

Keywords

ASJC Scopus subject areas

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