Nanocrystallization of poorly water soluble drugs for parenteral administration

Foziyah Zakir, Himanshu Sharma, Karandeep Kaur, Basant Malik, Bhuvaneshwer Vaidya, Amit K. Goyal, S. P. Vyas

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Approximately 50% active substances discovered by combinatorial chemistry and high-throughput screening show poor solubility in water. Out of various available approaches "Nanoedege technology" (Combination of Precipitation and Homogenization) was selected. Amphotericin B (Amp B) was used as a model drug. Three different preparations of Amp B were produced by using three different surfactants Tween80, Pluronic F68, Soya Lecithin and assessed for their efficacy and stability. In this study the Amp B nanosuspension formulation, with the smaller particle size, can be effectively produced with the Nanoedge Method. The pharmacokinetic profiles of Amp B when given in the nanosuspension formulation were different compared to the corresponding raw drug. Copyright © 2011 American Scientific Publishers All rights reserved.
Original languageEnglish (US)
Pages (from-to)127-129
Number of pages3
JournalJournal of Biomedical Nanotechnology
Issue number1
StatePublished - Jan 1 2011
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering
  • Pharmaceutical Science
  • Materials Science(all)
  • Medicine (miscellaneous)


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