Nano-Strategies for Lignin Biomaterials toward Cancer Therapy

Thenapakiam Sathasivam, Jing Kai, Sigit Sugiarto, Yong Yu, Debbie Xiang Yun Soo, Qiang Zhu, Jasmeen Merzaban*, Dan Kai*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Lignin is a nontoxic and biocompatible biopolymer with many promising characteristics, including a high tensile strength and antioxidant properties. This natural polymer can be processed through several chemical methods and modified into lignin nanomaterials for potential biomedical applications. This review summarizes the latest developments in nanolignin (NL)-based biomaterials for cancer therapy; various NL applications related to cancer therapy are considered, including drug and gene delivery, biosensing, bioimaging, and tissue engineering. The manuscript also outlines the potential use of these materials to improve the therapeutic potency of chemotherapeutic drugs by decreasing their dose and reducing their adverse effects. Due to its high surface area-to-volume ratio and the easy modification of its chemical components, NL could serve as an appropriate matrix for the binding and controlled release of various pharmaceutical agents. Moreover, the challenges in the utilization of NL-based materials for cancer therapy are discussed, along with the prospects of advances in such nanomaterials for medical research applications.

Original languageEnglish (US)
Article number2300024
JournalAdvanced healthcare materials
Issue number19
StatePublished - Jul 27 2023

Bibliographical note

Funding Information:
T.S. and J.K. contributed equally to this work. The authors gratefully acknowledge the financial support from CDA (Project No. CDA 202D800033), Agency for Science, Technology and Research (A*STAR).

Publisher Copyright:
© 2023 Wiley-VCH GmbH.


  • 3D printing
  • antioxidants
  • drug delivery
  • lignocellulose
  • nanotechnology
  • tissue engineering

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science


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