NAD+ depletion and defense in bacteria

Meng Wang; Qing Ji; Peng Liu; Yukun Liu

doi:10.1016/j.tim.2022.06.002

NAD⁺ depletion and defense in bacteria

Meng Wang, Qing Ji^*, Peng Liu, Yukun Liu

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

13 Scopus citations

Abstract

Depletion of nicotinamide adenine dinucleotide (NAD⁺), an important regulator of cellular energy metabolism, is a common strategy in immune-mediated cell death (ICD) in both prokaryotes and eukaryotes. Recent studies have revealed how bacteria use NAD⁺ depletion to protect against phages, providing insight into how eukaryotic ICD might have evolved.

Original language	English (US)
Pages (from-to)	435-438
Number of pages	4
Journal	Trends in Microbiology
Volume	31
Issue number	5
DOIs	https://doi.org/10.1016/j.tim.2022.06.002
State	Published - May 2023

Bibliographical note

Funding Information:
M.W., Q.J., and Y.L. are supported by the National Natural Science Foundation of China (No. 31960300 ) and Yunnan Youth Talent Support Program ( YNWR-QNBJ-2019-059 ). P.L. is supported by KAUST Office of Sponsored Research ( BAS/1/1037-01-01 and OSR-2019-CRG8-URF/1/4042 ). We apologize for the omission of some original references owing to space limitations.

Publisher Copyright:
© 2022 Elsevier Ltd

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tim.2022.06.002

Cite this

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title = "NAD+ depletion and defense in bacteria",

abstract = "Depletion of nicotinamide adenine dinucleotide (NAD+), an important regulator of cellular energy metabolism, is a common strategy in immune-mediated cell death (ICD) in both prokaryotes and eukaryotes. Recent studies have revealed how bacteria use NAD+ depletion to protect against phages, providing insight into how eukaryotic ICD might have evolved.",

author = "Meng Wang and Qing Ji and Peng Liu and Yukun Liu",

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AU - Ji, Qing

AU - Liu, Peng

AU - Liu, Yukun

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AB - Depletion of nicotinamide adenine dinucleotide (NAD+), an important regulator of cellular energy metabolism, is a common strategy in immune-mediated cell death (ICD) in both prokaryotes and eukaryotes. Recent studies have revealed how bacteria use NAD+ depletion to protect against phages, providing insight into how eukaryotic ICD might have evolved.

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