NAD+ depletion and defense in bacteria

Meng Wang, Qing Ji*, Peng Liu, Yukun Liu

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations


Depletion of nicotinamide adenine dinucleotide (NAD+), an important regulator of cellular energy metabolism, is a common strategy in immune-mediated cell death (ICD) in both prokaryotes and eukaryotes. Recent studies have revealed how bacteria use NAD+ depletion to protect against phages, providing insight into how eukaryotic ICD might have evolved.

Original languageEnglish (US)
Pages (from-to)435-438
Number of pages4
JournalTrends in Microbiology
Issue number5
StatePublished - May 2023

Bibliographical note

Funding Information:
M.W., Q.J., and Y.L. are supported by the National Natural Science Foundation of China (No. 31960300 ) and Yunnan Youth Talent Support Program ( YNWR-QNBJ-2019-059 ). P.L. is supported by KAUST Office of Sponsored Research ( BAS/1/1037-01-01 and OSR-2019-CRG8-URF/1/4042 ). We apologize for the omission of some original references owing to space limitations.

Publisher Copyright:
© 2022 Elsevier Ltd

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases


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