N-heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2

Orlando Santoro; Faïma Lazreg; Yury Minenkov; Luigi Cavallo; Catherine S. J. Cazin

doi:10.1039/C5DT03506F

N-heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2

Orlando Santoro, Faïma Lazreg, Yury Minenkov, Luigi Cavallo, Catherine S. J. Cazin

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Abstract

The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(I) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.

Original language	English (US)
Pages (from-to)	18138-18144
Number of pages	7
Journal	Dalton Trans.
Volume	44
Issue number	41
DOIs	https://doi.org/10.1039/C5DT03506F
State	Published - 2015

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abstract = "The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(I) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.",

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AU - Santoro, Orlando

AU - Lazreg, Faïma

AU - Minenkov, Yury

AU - Cavallo, Luigi

AU - Cazin, Catherine S. J.

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PY - 2015

Y1 - 2015

N2 - The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(I) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.

AB - The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(I) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.

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DO - 10.1039/C5DT03506F

M3 - Article

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JO - Dalton Trans.

JF - Dalton Trans.

IS - 41

ER -

N-heterocyclic carbene copper(I) catalysed N-methylation of amines using CO2

Abstract

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