Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats

Manana Kandashvili, Georgi Gamkrelidze, Lia Tsverava, Tamar Lordkipanidze, Eka Lepsveridze, Vincenzo Lagani, Maia Burjanadze, Manana Dashniani, Merab Kokaia, Revaz Solomonia

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS). A complex pathophysiological process referred to as epileptogenesis transforms a normal brain into an epileptic one. Prevention of epileptogenesis is a subject of intensive research. Cur-rently, there are no clinically approved drugs that can act as preventive medication. Our previous studies have revealed highly promising antiepileptogenic properties of a compound–myo-inositol (MI) and the present research broadens previous results and demonstrates the long-term disease-modifying effect of this drug, as well as the amelioration of cognitive comorbidities. For the first time, we show that long-term treatment with MI: (i) decreases the frequency and duration of elec-trographic SRS in the hippocampus; (ii) has an ameliorating effect on spatial learning and memory deficit associated with epileptogenesis, and (iii) attenuates cell loss in the hippocampus. MI treatment also alters the expression of the glial fibrillary acidic protein, LRRC8A subunit of volume-regulated anion channels, and protein tyrosine phosphatase receptor type R, all expected to coun-teract the epileptogenesis. All these effects are still present even 4 weeks after MI treatment ceased. This suggests that MI may exert multiple actions on various epileptogenesis-associated changes in the brain and, therefore, could be considered as a candidate target for prevention of epileptogenesis.
Original languageEnglish (US)
Pages (from-to)1198
JournalInternational Journal of Molecular Sciences
Volume23
Issue number3
DOIs
StatePublished - Jan 21 2022

ASJC Scopus subject areas

  • Organic Chemistry
  • Spectroscopy
  • Molecular Biology
  • Catalysis
  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Computer Science Applications

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