MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells

Noriyuki Sumida; Emmanouil G Sifakis; Narsis A Kiani; Anna Lewandowska Ronnegren; Barbara A Scholz; Johanna Vestlund; David Gomez-Cabrero; Jesper Tegner; Anita Göndör; Rolf Ohlsson

doi:10.1093/nar/gkaa817

MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells

Noriyuki Sumida, Emmanouil G Sifakis, Narsis A Kiani, Anna Lewandowska Ronnegren, Barbara A Scholz, Johanna Vestlund, David Gomez-Cabrero, Jesper Tegner, Anita Göndör, Rolf Ohlsson

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5 Scopus citations

Abstract

Abstract The relationship between stochastic transcriptional bursts and dynamic 3D chromatin states is not well understood. Using an innovated, ultra-sensitive technique, we address here enigmatic features underlying the communications between MYC and its enhancers in relation to the transcriptional process. MYC thus interacts with its flanking enhancers in a mutually exclusive manner documenting that enhancer hubs impinging on MYC detected in large cell populations likely do not exist in single cells. Dynamic encounters with pathologically activated enhancers responsive to a range of environmental cues, involved

Original language	English (US)
Journal	Nucleic Acids Research
DOIs	https://doi.org/10.1093/nar/gkaa817
State	Published - Oct 11 2020

Bibliographical note

KAUST Repository Item: Exported on 2020-10-19
Acknowledgements: The authors would like to acknowledge initial assistance from Drs Alejandro Woodbridge and Peter J Svensson as well as support from Science for Life Laboratory, the National Genomics Infrastructure, NGI, and Uppmax for providing assistance in massive parallel sequencing and computational infrastructure as well as the extensive data sets from ENCODE.

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10.1093/nar/gkaa817

https://repository.kaust.edu.sa/bitstream/10754/665615/1/MYC.pdf

Cite this

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title = "MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells",

abstract = "Abstract The relationship between stochastic transcriptional bursts and dynamic 3D chromatin states is not well understood. Using an innovated, ultra-sensitive technique, we address here enigmatic features underlying the communications between MYC and its enhancers in relation to the transcriptional process. MYC thus interacts with its flanking enhancers in a mutually exclusive manner documenting that enhancer hubs impinging on MYC detected in large cell populations likely do not exist in single cells. Dynamic encounters with pathologically activated enhancers responsive to a range of environmental cues, involved",

author = "Noriyuki Sumida and Sifakis, {Emmanouil G} and Kiani, {Narsis A} and Anna Lewandowska Ronnegren and Scholz, {Barbara A} and Johanna Vestlund and David Gomez-Cabrero and Jesper Tegner and Anita G{\"o}nd{\"o}r and Rolf Ohlsson",

note = "KAUST Repository Item: Exported on 2020-10-19 Acknowledgements: The authors would like to acknowledge initial assistance from Drs Alejandro Woodbridge and Peter J Svensson as well as support from Science for Life Laboratory, the National Genomics Infrastructure, NGI, and Uppmax for providing assistance in massive parallel sequencing and computational infrastructure as well as the extensive data sets from ENCODE.",

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doi = "10.1093/nar/gkaa817",

language = "English (US)",

journal = "Nucleic Acids Research",

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T1 - MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells

AU - Sumida, Noriyuki

AU - Sifakis, Emmanouil G

AU - Kiani, Narsis A

AU - Ronnegren, Anna Lewandowska

AU - Scholz, Barbara A

AU - Vestlund, Johanna

AU - Gomez-Cabrero, David

AU - Tegner, Jesper

AU - Göndör, Anita

AU - Ohlsson, Rolf

N1 - KAUST Repository Item: Exported on 2020-10-19 Acknowledgements: The authors would like to acknowledge initial assistance from Drs Alejandro Woodbridge and Peter J Svensson as well as support from Science for Life Laboratory, the National Genomics Infrastructure, NGI, and Uppmax for providing assistance in massive parallel sequencing and computational infrastructure as well as the extensive data sets from ENCODE.

PY - 2020/10/11

Y1 - 2020/10/11

N2 - Abstract The relationship between stochastic transcriptional bursts and dynamic 3D chromatin states is not well understood. Using an innovated, ultra-sensitive technique, we address here enigmatic features underlying the communications between MYC and its enhancers in relation to the transcriptional process. MYC thus interacts with its flanking enhancers in a mutually exclusive manner documenting that enhancer hubs impinging on MYC detected in large cell populations likely do not exist in single cells. Dynamic encounters with pathologically activated enhancers responsive to a range of environmental cues, involved

AB - Abstract The relationship between stochastic transcriptional bursts and dynamic 3D chromatin states is not well understood. Using an innovated, ultra-sensitive technique, we address here enigmatic features underlying the communications between MYC and its enhancers in relation to the transcriptional process. MYC thus interacts with its flanking enhancers in a mutually exclusive manner documenting that enhancer hubs impinging on MYC detected in large cell populations likely do not exist in single cells. Dynamic encounters with pathologically activated enhancers responsive to a range of environmental cues, involved

UR - http://hdl.handle.net/10754/665615

UR - https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa817/5922798

U2 - 10.1093/nar/gkaa817

DO - 10.1093/nar/gkaa817

M3 - Article

C2 - 33051686

SN - 0305-1048

JO - Nucleic Acids Research

JF - Nucleic Acids Research

ER -

MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells

Abstract

Bibliographical note

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