Muscle development during vertebrate limb outgrowth

Dirk Büscher*, Juan Carlos Izpisúa Belmonte

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Limb development has become one of the model systems for studying vertebrate development. One crucial aspect in limb development is the origin, differentiation and patterning of muscle. Much progress has been made in recent years towards understanding this process. One of the general observations is that the genes involved in limb muscle development appear to be very similar to those involved in muscle development in other regions of the embryo. In this review, we summarize some of the genes and mechanisms that regulate limb muscle development and discuss various avenues along which a deeper understanding can be gained of how muscle cells originate and differentiate in different tissues during vertebrate development.

Original languageEnglish (US)
Pages (from-to)131-139
Number of pages9
JournalCell and Tissue Research
Issue number1
StatePublished - 1999
Externally publishedYes


  • Development
  • Limb
  • Myogenesis
  • Somites
  • Transcription factors
  • Vertebrate

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology


Dive into the research topics of 'Muscle development during vertebrate limb outgrowth'. Together they form a unique fingerprint.

Cite this