Multiple sources of infection and potential endemic characteristics of the large outbreak of dengue in Guangdong in 2014

Shu Qun Shen; Hai Xia Wei; Yong Hang Fu; Hao Zhang; Qing Yi Mo; Xiao Jun Wang; Sheng Qun Deng; Wei Zhao; Yu Liu; Xiao Shuang Feng; Wei Chen; Hong Juan Peng

doi:10.1038/srep16913

Multiple sources of infection and potential endemic characteristics of the large outbreak of dengue in Guangdong in 2014

Shu Qun Shen, Hai Xia Wei, Yong Hang Fu, Hao Zhang, Qing Yi Mo, Xiao Jun Wang, Sheng Qun Deng, Wei Zhao, Yu Liu, Xiao Shuang Feng, Wei Chen, Hong Juan Peng^*

^*Corresponding author for this work

Physical Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

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Abstract

A large outbreak of dengue, with the most documented cases, occurred in Guangdong China in 2014. Epidemiological studies and phylogenetic analysis of the isolated dengue virus (DENV) showed this outbreak was attributed to multiple sources and caused by at least two genotypes of DENV-1 (Genotypes I and III) and two genotypes of DENV-2 (Cosmopolitan and Asian I Genotypes). A retrospective review and phylogenetic analysis of DENV isolated in Guangdong showed that DENV-1 Genotype I strains were reported continuously during 2004-2014, Genotype III strains were reported during 2009-2014; DENV-2 Cosmopolitan and Asian I Genotype strains were reported continuously during 2012-2014. At least 45,171 cases were reported in this outbreak, with 65.9% of the patients in the 21-55-year-old group. A trend toward a decrease in the daily newly emerged cases lagged by approximately 20 days compared with the mosquito density curve. Several epidemiological characteristics of this outbreak and the stably sustained serotypes and genotypes of DENV isolated in Guangdong suggest that Guangdong has been facing a threat of transforming from a dengue epidemic area to an endemic area. The high temperature, drenching rain, rapid urbanization, and pandemic of dengue in Southeast Asia may have contributed to this large outbreak of dengue.

Original language	English (US)
Article number	16913
Journal	Scientific Reports
Volume	5
DOIs	https://doi.org/10.1038/srep16913
State	Published - Nov 23 2015

Bibliographical note

Funding Information:
The authors thank the Health Department of Guangdong Province and Guangdong Province CDC for providing the epidemiological data for dengue cases and mosquito surveillance data. This research is supported by the funding of National Natural Science Foundation of China (No. 81271866, 81572012) and Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2014) to HJP. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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title = "Multiple sources of infection and potential endemic characteristics of the large outbreak of dengue in Guangdong in 2014",

abstract = "A large outbreak of dengue, with the most documented cases, occurred in Guangdong China in 2014. Epidemiological studies and phylogenetic analysis of the isolated dengue virus (DENV) showed this outbreak was attributed to multiple sources and caused by at least two genotypes of DENV-1 (Genotypes I and III) and two genotypes of DENV-2 (Cosmopolitan and Asian I Genotypes). A retrospective review and phylogenetic analysis of DENV isolated in Guangdong showed that DENV-1 Genotype I strains were reported continuously during 2004-2014, Genotype III strains were reported during 2009-2014; DENV-2 Cosmopolitan and Asian I Genotype strains were reported continuously during 2012-2014. At least 45,171 cases were reported in this outbreak, with 65.9% of the patients in the 21-55-year-old group. A trend toward a decrease in the daily newly emerged cases lagged by approximately 20 days compared with the mosquito density curve. Several epidemiological characteristics of this outbreak and the stably sustained serotypes and genotypes of DENV isolated in Guangdong suggest that Guangdong has been facing a threat of transforming from a dengue epidemic area to an endemic area. The high temperature, drenching rain, rapid urbanization, and pandemic of dengue in Southeast Asia may have contributed to this large outbreak of dengue.",

author = "Shen, {Shu Qun} and Wei, {Hai Xia} and Fu, {Yong Hang} and Hao Zhang and Mo, {Qing Yi} and Wang, {Xiao Jun} and Deng, {Sheng Qun} and Wei Zhao and Yu Liu and Feng, {Xiao Shuang} and Wei Chen and Peng, {Hong Juan}",

note = "Funding Information: The authors thank the Health Department of Guangdong Province and Guangdong Province CDC for providing the epidemiological data for dengue cases and mosquito surveillance data. This research is supported by the funding of National Natural Science Foundation of China (No. 81271866, 81572012) and Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2014) to HJP. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.",

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AU - Shen, Shu Qun

AU - Wei, Hai Xia

AU - Fu, Yong Hang

AU - Zhang, Hao

AU - Mo, Qing Yi

AU - Wang, Xiao Jun

AU - Deng, Sheng Qun

AU - Zhao, Wei

AU - Liu, Yu

AU - Feng, Xiao Shuang

AU - Chen, Wei

AU - Peng, Hong Juan

N1 - Funding Information: The authors thank the Health Department of Guangdong Province and Guangdong Province CDC for providing the epidemiological data for dengue cases and mosquito surveillance data. This research is supported by the funding of National Natural Science Foundation of China (No. 81271866, 81572012) and Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2014) to HJP. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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N2 - A large outbreak of dengue, with the most documented cases, occurred in Guangdong China in 2014. Epidemiological studies and phylogenetic analysis of the isolated dengue virus (DENV) showed this outbreak was attributed to multiple sources and caused by at least two genotypes of DENV-1 (Genotypes I and III) and two genotypes of DENV-2 (Cosmopolitan and Asian I Genotypes). A retrospective review and phylogenetic analysis of DENV isolated in Guangdong showed that DENV-1 Genotype I strains were reported continuously during 2004-2014, Genotype III strains were reported during 2009-2014; DENV-2 Cosmopolitan and Asian I Genotype strains were reported continuously during 2012-2014. At least 45,171 cases were reported in this outbreak, with 65.9% of the patients in the 21-55-year-old group. A trend toward a decrease in the daily newly emerged cases lagged by approximately 20 days compared with the mosquito density curve. Several epidemiological characteristics of this outbreak and the stably sustained serotypes and genotypes of DENV isolated in Guangdong suggest that Guangdong has been facing a threat of transforming from a dengue epidemic area to an endemic area. The high temperature, drenching rain, rapid urbanization, and pandemic of dengue in Southeast Asia may have contributed to this large outbreak of dengue.

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Multiple sources of infection and potential endemic characteristics of the large outbreak of dengue in Guangdong in 2014

Abstract

Bibliographical note

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UN SDGs

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