We demonstrate a novel, feasible strategy on practical application of UV photodetectors using multiple-shelled hollow ZnO microspheres integrated by nanodots for space application with omnidirectional sensitivity. Due to the resonance-assisted effect by the convex shells, the microsphere devices exhibits enhanced photoresponse with photogain of G ~ 10. Moreover, the response and recovery speed are promoted (response/recovery times: 0.8/1.2 ms) because of the existence of junction barriers between microspheres. We also demonstrated the omnidirectional detectability and proton tolerance ability of the microsphere devices as a reliable test for space use. The concept employing multiple-shelled hollow ZnO microspheres paves a new way to realize nanostructured photodetectors using in harsh environment and space mission.