Abstract
Temperature and pH responsive poly(N-isopropylacrylamide-co-methacrylic acid) (P(NIPAAm-co-MAA)) microcontainers with encapsulated magnetic nanoparticles in the shell were prepared by a two-stage distillation precipitation polymerization. PMAA@Fe 3O 4/P(NIPAAm-co-MAA) core-shell nanoparticles were synthesized by the second-stage polymerization of NIPAAm, MAA and N, N′-methylenebisacrylamide as crosslinker in the presence of magnetic nanoparticles and PMAA as core. These novel triple-functional microcontainers were prepared by selective removal of the PMAA core in water. Daunorubicin hydrochloride (DNR) was loaded into the microcontainers and the release profile was studied by UV-visible spectroscopy. The synthesized nanostructures were characterized with transmission and scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy. The magnetic properties were evaluated by vibrating sample magnetometry. The shrink and swelling behavior was studied by dynamic light scattering.
Original language | English (US) |
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Pages (from-to) | 888-894 |
Number of pages | 7 |
Journal | Polymer International |
Volume | 61 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2012 |
Externally published | Yes |
Keywords
- Daunorubicin
- Distillation precipitation polymerization
- Magnetic nanoparticles
- Microcontainers
- PH sensitive
- Thermosensitive
ASJC Scopus subject areas
- Polymers and Plastics
- Organic Chemistry
- Materials Chemistry