Multi-responsive polymeric microcontainers for potential biomedical applications: Synthesis and functionality evaluation

Panayiotis Bilalis; Eleni K. Efthimiadou; Alexandros Chatzipavlidis; Nikos Boukos; George C. Kordas

doi:10.1002/pi.4152

Multi-responsive polymeric microcontainers for potential biomedical applications: Synthesis and functionality evaluation

Panayiotis Bilalis, Eleni K. Efthimiadou, Alexandros Chatzipavlidis, Nikos Boukos, George C. Kordas^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Temperature and pH responsive poly(N-isopropylacrylamide-co-methacrylic acid) (P(NIPAAm-co-MAA)) microcontainers with encapsulated magnetic nanoparticles in the shell were prepared by a two-stage distillation precipitation polymerization. PMAA@Fe ₃O ₄/P(NIPAAm-co-MAA) core-shell nanoparticles were synthesized by the second-stage polymerization of NIPAAm, MAA and N, N′-methylenebisacrylamide as crosslinker in the presence of magnetic nanoparticles and PMAA as core. These novel triple-functional microcontainers were prepared by selective removal of the PMAA core in water. Daunorubicin hydrochloride (DNR) was loaded into the microcontainers and the release profile was studied by UV-visible spectroscopy. The synthesized nanostructures were characterized with transmission and scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy. The magnetic properties were evaluated by vibrating sample magnetometry. The shrink and swelling behavior was studied by dynamic light scattering.

Original language	English (US)
Pages (from-to)	888-894
Number of pages	7
Journal	Polymer International
Volume	61
Issue number	6
DOIs	https://doi.org/10.1002/pi.4152
State	Published - Jun 2012
Externally published	Yes

Keywords

Daunorubicin
Distillation precipitation polymerization
Magnetic nanoparticles
Microcontainers
PH sensitive
Thermosensitive

ASJC Scopus subject areas

Polymers and Plastics
Organic Chemistry
Materials Chemistry

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10.1002/pi.4152

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title = "Multi-responsive polymeric microcontainers for potential biomedical applications: Synthesis and functionality evaluation",

abstract = "Temperature and pH responsive poly(N-isopropylacrylamide-co-methacrylic acid) (P(NIPAAm-co-MAA)) microcontainers with encapsulated magnetic nanoparticles in the shell were prepared by a two-stage distillation precipitation polymerization. PMAA@Fe 3O 4/P(NIPAAm-co-MAA) core-shell nanoparticles were synthesized by the second-stage polymerization of NIPAAm, MAA and N, N′-methylenebisacrylamide as crosslinker in the presence of magnetic nanoparticles and PMAA as core. These novel triple-functional microcontainers were prepared by selective removal of the PMAA core in water. Daunorubicin hydrochloride (DNR) was loaded into the microcontainers and the release profile was studied by UV-visible spectroscopy. The synthesized nanostructures were characterized with transmission and scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy. The magnetic properties were evaluated by vibrating sample magnetometry. The shrink and swelling behavior was studied by dynamic light scattering.",

keywords = "Daunorubicin, Distillation precipitation polymerization, Magnetic nanoparticles, Microcontainers, PH sensitive, Thermosensitive",

author = "Panayiotis Bilalis and Efthimiadou, {Eleni K.} and Alexandros Chatzipavlidis and Nikos Boukos and Kordas, {George C.}",

year = "2012",

month = jun,

doi = "10.1002/pi.4152",

language = "English (US)",

volume = "61",

pages = "888--894",

journal = "Polymer International",

issn = "0959-8103",

publisher = "Wiley",

number = "6",

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T1 - Multi-responsive polymeric microcontainers for potential biomedical applications

T2 - Synthesis and functionality evaluation

AU - Bilalis, Panayiotis

AU - Efthimiadou, Eleni K.

AU - Chatzipavlidis, Alexandros

AU - Boukos, Nikos

AU - Kordas, George C.

PY - 2012/6

Y1 - 2012/6

N2 - Temperature and pH responsive poly(N-isopropylacrylamide-co-methacrylic acid) (P(NIPAAm-co-MAA)) microcontainers with encapsulated magnetic nanoparticles in the shell were prepared by a two-stage distillation precipitation polymerization. PMAA@Fe 3O 4/P(NIPAAm-co-MAA) core-shell nanoparticles were synthesized by the second-stage polymerization of NIPAAm, MAA and N, N′-methylenebisacrylamide as crosslinker in the presence of magnetic nanoparticles and PMAA as core. These novel triple-functional microcontainers were prepared by selective removal of the PMAA core in water. Daunorubicin hydrochloride (DNR) was loaded into the microcontainers and the release profile was studied by UV-visible spectroscopy. The synthesized nanostructures were characterized with transmission and scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy. The magnetic properties were evaluated by vibrating sample magnetometry. The shrink and swelling behavior was studied by dynamic light scattering.

AB - Temperature and pH responsive poly(N-isopropylacrylamide-co-methacrylic acid) (P(NIPAAm-co-MAA)) microcontainers with encapsulated magnetic nanoparticles in the shell were prepared by a two-stage distillation precipitation polymerization. PMAA@Fe 3O 4/P(NIPAAm-co-MAA) core-shell nanoparticles were synthesized by the second-stage polymerization of NIPAAm, MAA and N, N′-methylenebisacrylamide as crosslinker in the presence of magnetic nanoparticles and PMAA as core. These novel triple-functional microcontainers were prepared by selective removal of the PMAA core in water. Daunorubicin hydrochloride (DNR) was loaded into the microcontainers and the release profile was studied by UV-visible spectroscopy. The synthesized nanostructures were characterized with transmission and scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy. The magnetic properties were evaluated by vibrating sample magnetometry. The shrink and swelling behavior was studied by dynamic light scattering.

KW - Daunorubicin

KW - Distillation precipitation polymerization

KW - Magnetic nanoparticles

KW - Microcontainers

KW - PH sensitive

KW - Thermosensitive

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DO - 10.1002/pi.4152

M3 - Article

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SN - 0959-8103

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SP - 888

EP - 894

JO - Polymer International

JF - Polymer International

IS - 6

ER -

Multi-responsive polymeric microcontainers for potential biomedical applications: Synthesis and functionality evaluation

Abstract

Keywords

ASJC Scopus subject areas

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