Multi-ConDoS: Multimodal Contrastive Domain Sharing Generative Adversarial Networks for Self-Supervised Medical Image Segmentation

Jiaojiao Zhang, Shuo Zhang, Xiaoqian Shen, Thomas Lukasiewicz, Zhenghua Xu

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Existing self-supervised medical image segmentation usually encounters the domain shift problem (i.e., the input distribution of pre-training is different from that of fine-tuning) and/or the multimodality problem (i.e., it is based on single-modal data only and cannot utilize the fruitful multimodal information of medical images). To solve these problems, in this work, we propose multimodal contrastive domain sharing (Multi-ConDoS) generative adversarial networks to achieve effective multimodal contrastive self-supervised medical image segmentation. Compared to the existing self-supervised approaches, Multi-ConDoS has the following three advantages: (i) it utilizes multimodal medical images to learn more comprehensive object features via multimodal contrastive learning; (ii) domain translation is achieved by integrating the cyclic learning strategy of CycleGAN and the cross-domain translation loss of Pix2Pix; (iii) novel domain sharing layers are introduced to learn not only domain-specific but also domain-sharing information from the multimodal medical images. Extensive experiments on two publicly multimodal medical image segmentation datasets show that, with only 5% (resp., 10%) of labeled data, Multi-ConDoS not only greatly outperforms the state-of-the-art self-supervised and semi-supervised medical image segmentation baselines with the same ratio of labeled data, but also achieves similar (sometimes even better) performances as fully supervised segmentation methods with 50% (resp., 100%) of labeled data, which thus proves that our work can achieve superior segmentation performances with very low labeling workload. Furthermore, ablation studies prove that the above three improvements are all effective and essential for Multi-ConDoS to achieve this very superior performance.
Original languageEnglish (US)
Pages (from-to)1-1
Number of pages1
JournalIEEE Transactions on Medical Imaging
StatePublished - Jun 28 2023

Bibliographical note

KAUST Repository Item: Exported on 2023-07-17
Acknowledgements: This work was supported by the National Natural Science Foundation of China under the grants 62276089 and 61906063, by the Natural Science Foundation of Hebei Province, China, under the grant F2021202064, and by the Key Research and Development Project of Hainan Province, China, under the grant ZDYF2022SHFZ015. This work was also supported by the AXA Research Fund.


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