Monolithic stationary phases for enantioselective capillary electrochromatography

Michael Lämmerhofer, Frantisek Svec*, Jean M.J. Fréchet, Wolfgang Lindner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Monolithic capillary electrochromatography (CEC) columns containing polymerized quinidine carbamate units have been prepared and used for enantioselective separations of modified amino acids. Optimization of both monolithic structure and mobile phase variables such as the ionic strength, type, and composition of eluent affords enantioselective CEC separations characterized by both high resolution and efficiency. For example, an efficiency of up to 250,000 plates/m was achieved for the separation of 2,4-dinitrophenyl-derivatized amino acids. The simple preparation together with the large variability of readily available chemistries make the monolithic separation media an attractive alternative to capillary columns packed with beads.

Original languageEnglish (US)
Pages (from-to)597-602
Number of pages6
JournalJournal of Microcolumn Separations
Issue number12
StatePublished - Dec 2000
Externally publishedYes


  • CEC
  • Capillary
  • Column
  • Copolymer
  • Electrochromatography
  • Enantioselective
  • Monolith
  • Nonaqueous
  • Quinidine carbamate monomer

ASJC Scopus subject areas

  • Mechanical Engineering
  • Filtration and Separation


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