Mitochondrial regulation in pluripotent stem cells

Xiuling Xu, Shunlei Duan, Fei Yi, Alejandro Ocampo, Guang Hui Liu*, Juan Carlos Izpisua Belmonte

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

308 Scopus citations

Abstract

Due to their fundamental role in energy production, mitochondria have been traditionally known as the powerhouse of the cell. Recent discoveries have suggested crucial roles of mitochondria in the maintenance of pluripotency, differentiation, and reprogramming of induced pluripotent stem cells (iPSCs). While glycolytic energy production is observed at pluripotent states, an increase in mitochondrial oxidative phosphorylation is necessary for cell differentiation. Consequently, a transition from somatic mitochondrial oxidative metabolism to glycolysis seems to be required for successful reprogramming. Future research aiming to dissect the roles of mitochondria in the establishment and homeostasis of pluripotency, as well as combining cell reprogramming with gene editing technologies, may unearth novel insights into our understanding of mitochondrial diseases and aging.

Original languageEnglish (US)
Pages (from-to)325-332
Number of pages8
JournalCell Metabolism
Volume18
Issue number3
DOIs
StatePublished - Sep 3 2013
Externally publishedYes

Bibliographical note

Funding Information:
G.-H.L. is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01020312), NSFC (81271266, 31222039), the Thousand Young Talents program of China, National Laboratory of Biomacromolecules (2013kf05, 2013kf11), and State Key Laboratory of Drug Research (SIMM1302KF-17). X.X. was supported by NSFC (31201111). J.C.I.B. was supported by TERCEL-ISCIII-MINECO, Fundacion Cellex, G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust, The Glenn Center for Aging Research and The Ellison Medical Foundation.

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Mitochondrial regulation in pluripotent stem cells'. Together they form a unique fingerprint.

Cite this