Mitochondrial membrane potential and neuronal glutamate excitotoxicity: Mortality and millivolts

David G. Nicholls*, Manus W. Ward

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

499 Scopus citations


In the past few years it has become apparent that mitochondria have an essential role in the life and death of neuronal and non-neuronal cells. The central mitochondrial bioenergetic parameter is the protonmotive force, Δp. Much research has focused on the monitoring of the major component of Δp, the mitochondrial membrane potential Δψ(m), in intact neurones exposed to excitotoxic stimuli, in the hope of establishing the causal relationships between cell death and mitochondrial dysfunction. Several fluorescent techniques have been used, and this article discusses their merits and pitfalls. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)166-174
Number of pages9
JournalTrends in Neurosciences
Issue number4
StatePublished - Apr 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


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