TY - JOUR
T1 - Mitochondrial membrane potential and neuronal glutamate excitotoxicity
T2 - Mortality and millivolts
AU - Nicholls, David G.
AU - Ward, Manus
PY - 2000/4/1
Y1 - 2000/4/1
N2 - In the past few years it has become apparent that mitochondria have an essential role in the life and death of neuronal and non-neuronal cells. The central mitochondrial bioenergetic parameter is the protonmotive force, Δp. Much research has focused on the monitoring of the major component of Δp, the mitochondrial membrane potential Δψ(m), in intact neurones exposed to excitotoxic stimuli, in the hope of establishing the causal relationships between cell death and mitochondrial dysfunction. Several fluorescent techniques have been used, and this article discusses their merits and pitfalls. Copyright (C) 2000 Elsevier Science Ltd.
AB - In the past few years it has become apparent that mitochondria have an essential role in the life and death of neuronal and non-neuronal cells. The central mitochondrial bioenergetic parameter is the protonmotive force, Δp. Much research has focused on the monitoring of the major component of Δp, the mitochondrial membrane potential Δψ(m), in intact neurones exposed to excitotoxic stimuli, in the hope of establishing the causal relationships between cell death and mitochondrial dysfunction. Several fluorescent techniques have been used, and this article discusses their merits and pitfalls. Copyright (C) 2000 Elsevier Science Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0034176843&partnerID=8YFLogxK
U2 - 10.1016/S0166-2236(99)01534-9
DO - 10.1016/S0166-2236(99)01534-9
M3 - Review article
C2 - 10717676
AN - SCOPUS:0034176843
SN - 0166-2236
VL - 23
SP - 166
EP - 174
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 4
ER -