Miniaturized drug delivery system for biomedical applications

Khalil Moussi; Mohammed AlDajani; Jürgen Kosel

doi:10.1109/NEMS.2019.8915621

Miniaturized drug delivery system for biomedical applications

Khalil Moussi, Mohammed AlDajani, Jürgen Kosel

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Scopus citations

Abstract

A miniaturized 3D printed drug delivery device powered wirelessly is presented. The device is composed of an electrochemical micropump, a 3D printed reservoir with microneedles, and a wireless powering unit. The electrochemical pump features an expandable (up to 300%) Parylene C micro-bellows membrane fabricated by mold casting, using a two-photon polymerization 3D printing technique. The hollow microneedles are 100 μm in diameter and 300 μm long. The fabrication process offers customizable device properties, where the shape, size, and performance can be tailored to fit a wide range of in vivo drug delivery applications. Delivery of 3.8 ± 0.3 μL within 10 seconds of actuation is demonstrated, using inductive wireless powering at a distance of 10 mm between the primary and secondary coils.

Original language	English (US)
Title of host publication	2019 IEEE 14th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)
Publisher	IEEE
Pages	97-100
Number of pages	4
ISBN (Print)	9781728116297
DOIs	https://doi.org/10.1109/NEMS.2019.8915621
State	Published - Nov 29 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was funded and supported by King Abdullah University of Science and Technology (KAUST).

Access to Document

10.1109/NEMS.2019.8915621

https://repository.kaust.edu.sa/bitstream/10754/661047/1/Miniaturized%20Drug%20Delivery%20System%20for%20Biomedical%20Applications.pdf

Cite this

@inproceedings{ec851a18b9944cf3a950d0c9fbfa5f7a,

title = "Miniaturized drug delivery system for biomedical applications",

abstract = "A miniaturized 3D printed drug delivery device powered wirelessly is presented. The device is composed of an electrochemical micropump, a 3D printed reservoir with microneedles, and a wireless powering unit. The electrochemical pump features an expandable (up to 300%) Parylene C micro-bellows membrane fabricated by mold casting, using a two-photon polymerization 3D printing technique. The hollow microneedles are 100 μm in diameter and 300 μm long. The fabrication process offers customizable device properties, where the shape, size, and performance can be tailored to fit a wide range of in vivo drug delivery applications. Delivery of 3.8 ± 0.3 μL within 10 seconds of actuation is demonstrated, using inductive wireless powering at a distance of 10 mm between the primary and secondary coils.",

author = "Khalil Moussi and Mohammed AlDajani and J{\"u}rgen Kosel",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was funded and supported by King Abdullah University of Science and Technology (KAUST).",

year = "2019",

month = nov,

day = "29",

doi = "10.1109/NEMS.2019.8915621",

language = "English (US)",

isbn = "9781728116297",

pages = "97--100",

booktitle = "2019 IEEE 14th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)",

publisher = "IEEE",

}

TY - GEN

T1 - Miniaturized drug delivery system for biomedical applications

AU - Moussi, Khalil

AU - AlDajani, Mohammed

AU - Kosel, Jürgen

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was funded and supported by King Abdullah University of Science and Technology (KAUST).

PY - 2019/11/29

Y1 - 2019/11/29

N2 - A miniaturized 3D printed drug delivery device powered wirelessly is presented. The device is composed of an electrochemical micropump, a 3D printed reservoir with microneedles, and a wireless powering unit. The electrochemical pump features an expandable (up to 300%) Parylene C micro-bellows membrane fabricated by mold casting, using a two-photon polymerization 3D printing technique. The hollow microneedles are 100 μm in diameter and 300 μm long. The fabrication process offers customizable device properties, where the shape, size, and performance can be tailored to fit a wide range of in vivo drug delivery applications. Delivery of 3.8 ± 0.3 μL within 10 seconds of actuation is demonstrated, using inductive wireless powering at a distance of 10 mm between the primary and secondary coils.

AB - A miniaturized 3D printed drug delivery device powered wirelessly is presented. The device is composed of an electrochemical micropump, a 3D printed reservoir with microneedles, and a wireless powering unit. The electrochemical pump features an expandable (up to 300%) Parylene C micro-bellows membrane fabricated by mold casting, using a two-photon polymerization 3D printing technique. The hollow microneedles are 100 μm in diameter and 300 μm long. The fabrication process offers customizable device properties, where the shape, size, and performance can be tailored to fit a wide range of in vivo drug delivery applications. Delivery of 3.8 ± 0.3 μL within 10 seconds of actuation is demonstrated, using inductive wireless powering at a distance of 10 mm between the primary and secondary coils.

UR - http://hdl.handle.net/10754/661047

UR - https://ieeexplore.ieee.org/document/8915621/

UR - http://www.scopus.com/inward/record.url?scp=85076687590&partnerID=8YFLogxK

U2 - 10.1109/NEMS.2019.8915621

DO - 10.1109/NEMS.2019.8915621

M3 - Conference contribution

SN - 9781728116297

SP - 97

EP - 100

BT - 2019 IEEE 14th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

PB - IEEE

ER -

Miniaturized drug delivery system for biomedical applications

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this