Mini-review: Marine natural products and their synthetic analogs as antifouling compounds: 2009–2014

Pei-Yuan Qian, Zhongrui Li, Ying Xu, Yongxin Li, Nobuhiro Fusetani

Research output: Contribution to journalArticlepeer-review

148 Scopus citations


This review covers 214 marine natural compounds and 23 of their synthetic analogs, which were discovered and/or synthesized from mid-2009 to August 2014. The antifouling (AF) compounds reported have medium to high bioactivity (with a threshold of EC50 < 15.0 mg ml−1). Among these compounds, 82 natural compounds were identified as new structures. All the compounds are marine-derived, demonstrating that marine organisms are prolific and promising sources of natural products that may be developed as environmentally friendly antifoulants. However, this mini-review excludes more than 200 compounds that were also reported as AF compounds but with rather weak bioactivity during the same period. Also excluded are terrestrial-derived AF compounds reported during the last five years. A brief discussion on current challenges in AF compound research is also provided to reflect the authors’ own views in terms of future research directions.
Original languageEnglish (US)
Pages (from-to)101-122
Number of pages22
Issue number1
StatePublished - Jan 26 2015
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2021-03-31
Acknowledged KAUST grant number(s): SA-C0040/UK-C0016
Acknowledgements: This work was supported by a grant [DY125-15-T-02] from the China Ocean Mineral Resources Research and Development Association, a grant [SIDSSE-201206] from the Sanya Institute of Deep Sea Science and Engineering, a GRC grant [GRF661611] from Hong Kong Special Administrative Region, and award [SA-C0040/UK-C0016] from King Abdullah University of Science and Technology.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Water Science and Technology
  • Aquatic Science


Dive into the research topics of 'Mini-review: Marine natural products and their synthetic analogs as antifouling compounds: 2009–2014'. Together they form a unique fingerprint.

Cite this