Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

Zhiqiang Weng; Huaifeng Li; Weiming He; Liangfeng Yao; Jianwei Tan; Jinfa Chen; Yaofeng Yuan; Kuo-Wei Huang

doi:10.1016/j.tet.2011.12.085

Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

Zhiqiang Weng, Huaifeng Li, Weiming He, Liangfeng Yao, Jianwei Tan, Jinfa Chen, Yaofeng Yuan, Kuo-Wei Huang

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

A catalytic process for trifluoromethylation of terminal alkynes with Togni's reagent has been developed, affording trifluoromethylated acetylenes in good to excellent yields. The reaction is conducted at room temperature and exhibits tolerance to a range of functional groups. © 2012 Elsevier Ltd. All rights reserved.

Original language	English (US)
Pages (from-to)	2527-2531
Number of pages	5
Journal	Tetrahedron
Volume	68
Issue number	11
DOIs	https://doi.org/10.1016/j.tet.2011.12.085
State	Published - Mar 2012

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We acknowledge the financial support from King Abdullah University of Science and Technology to K.-W.H. and from National Natural Science Foundation of China (21072030) and Fuzhou University (022318) to Z.W.

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/j.tet.2011.12.085

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title = "Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent",

abstract = "A catalytic process for trifluoromethylation of terminal alkynes with Togni's reagent has been developed, affording trifluoromethylated acetylenes in good to excellent yields. The reaction is conducted at room temperature and exhibits tolerance to a range of functional groups. {\textcopyright} 2012 Elsevier Ltd. All rights reserved.",

author = "Zhiqiang Weng and Huaifeng Li and Weiming He and Liangfeng Yao and Jianwei Tan and Jinfa Chen and Yaofeng Yuan and Kuo-Wei Huang",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: We acknowledge the financial support from King Abdullah University of Science and Technology to K.-W.H. and from National Natural Science Foundation of China (21072030) and Fuzhou University (022318) to Z.W.",

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T1 - Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

AU - Weng, Zhiqiang

AU - Li, Huaifeng

AU - He, Weiming

AU - Yao, Liangfeng

AU - Tan, Jianwei

AU - Chen, Jinfa

AU - Yuan, Yaofeng

AU - Huang, Kuo-Wei

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: We acknowledge the financial support from King Abdullah University of Science and Technology to K.-W.H. and from National Natural Science Foundation of China (21072030) and Fuzhou University (022318) to Z.W.

PY - 2012/3

Y1 - 2012/3

N2 - A catalytic process for trifluoromethylation of terminal alkynes with Togni's reagent has been developed, affording trifluoromethylated acetylenes in good to excellent yields. The reaction is conducted at room temperature and exhibits tolerance to a range of functional groups. © 2012 Elsevier Ltd. All rights reserved.

AB - A catalytic process for trifluoromethylation of terminal alkynes with Togni's reagent has been developed, affording trifluoromethylated acetylenes in good to excellent yields. The reaction is conducted at room temperature and exhibits tolerance to a range of functional groups. © 2012 Elsevier Ltd. All rights reserved.

UR - http://hdl.handle.net/10754/562120

UR - https://linkinghub.elsevier.com/retrieve/pii/S0040402011019818

UR - http://www.scopus.com/inward/record.url?scp=84862776574&partnerID=8YFLogxK

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M3 - Article

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SP - 2527

EP - 2531

JO - Tetrahedron

JF - Tetrahedron

IS - 11

ER -

Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent

Abstract

Bibliographical note

ASJC Scopus subject areas

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