Microvilli Adhesion: An Alternative Route for Nanoparticle Cell Internalization

Patrizia Sommi, Agostina Vitali, Stefania Coniglio, Daniele Callegari, Sofia Barbieri, Alberto Casu, Andrea Falqui, Lorenzo Vigano’, Barbara Vigani, Franca Ferrari, Umberto Anselmi-Tamburini

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The cellular uptake of nanoparticles (NPs) represents a critical step in nanomedicine and a crucial point for understanding the interaction of nanomaterials with biological systems. No specific mechanism of uptake has been identified so far, as the NPs are generally incorporated by the cells through one of the few well-known endocytotic mechanisms. Here, an alternative internalization route mediated by microvilli adhesion is demonstrated. This microvillus-mediated adhesion (MMA) has been observed using ceria and magnetite NPs with a dimension of
Original languageEnglish (US)
Pages (from-to)15803-15814
Number of pages12
JournalACS Nano
Issue number10
StatePublished - Sep 29 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-11-24
Acknowledgements: We are grateful to A. Ottolenghi, Department of Physics, University of Pavia, for the use of the Attune NxT cytofluorimeter; P. Pallavicini, Department of Chemistry, University of Pavia, for the use of DLS; Centro Interdipartimentale di Studi e Ricerca per la Conservazione del Patrimonio Culturale (CISRiC), University of Pavia, for providing access to HRSEM; C. Di Benedetto, King Abdullah University of Science and Technology (KAUST), for TEM sample preparation and image acquisition; and Centro Grandi Strumenti, University of Pavia, for confocal microscopy and flow cytometry (BD FACSLyric System). We thank U. Laforenza and G. Pellavio, Department of Molecular Medicine, University of Pavia, for providing us with human mesothelioma cell lines. Part of this work was financially supported by Fondazione Banca del Monte di Lombardia to U.A.-T., as well as by KAUST Baseline funding to A.F.

ASJC Scopus subject areas

  • General Physics and Astronomy
  • General Materials Science
  • General Engineering


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