TY - JOUR
T1 - MicroRNAs contribute to induced pluripotent stem cell somatic donor memory
AU - Vitaloni, Marianna
AU - Pulecio, Julian
AU - Bilic, Josipa
AU - Kuebler, Bernd
AU - Laricchia-Robbio, Leopoldo
AU - Belmonte, Juan Carlos Izpisua
PY - 2014/1/24
Y1 - 2014/1/24
N2 - Background: iPSCs retain marks of their donor population: "somatic donor memory," which facilitates iPSC differentiation back into their original tissue. Results: Specific microRNAs maintain their expression in HPC-derived iPSCs promoting their differentiation back to HPCs. Conclusion: miRNA contributes to iPSC somatic donor memory. Significance: miRNA donor memory may offer a tool to understand iPSC reprogramming and differentiation toward a particular somatic population.
AB - Background: iPSCs retain marks of their donor population: "somatic donor memory," which facilitates iPSC differentiation back into their original tissue. Results: Specific microRNAs maintain their expression in HPC-derived iPSCs promoting their differentiation back to HPCs. Conclusion: miRNA contributes to iPSC somatic donor memory. Significance: miRNA donor memory may offer a tool to understand iPSC reprogramming and differentiation toward a particular somatic population.
UR - http://www.scopus.com/inward/record.url?scp=84893036605&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.538702
DO - 10.1074/jbc.M113.538702
M3 - Article
C2 - 24311783
AN - SCOPUS:84893036605
SN - 0021-9258
VL - 289
SP - 2084
EP - 2098
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 4
ER -