Microfluidic platforms for cell cultures and investigations

Maria Laura Coluccio; Gerardo Perozziello; Natalia Malara; Elvira Parrotta; Peng Zhang; Francesco Gentile; Tania Limongi; Pushparani Michael Raj; Gianni Cuda; Patrizio Candeloro; Enzo M. Di Fabrizio

doi:10.1016/j.mee.2019.01.004

Microfluidic platforms for cell cultures and investigations

Maria Laura Coluccio, Gerardo Perozziello, Natalia Malara, Elvira Parrotta, Peng Zhang, Francesco Gentile, Tania Limongi, Pushparani Michael Raj, Gianni Cuda, Patrizio Candeloro, Enzo M. Di Fabrizio

Research output: Contribution to journal › Article › peer-review

148 Scopus citations

Abstract

This review covers several aspects of microfluidic devices used for culturing and monitoring of both adherent and non-adherent cells, including a multitude of applications. A comparison of available platforms with high throughput analysis, automation capability, interface to sensors and integration, is reported. Aspects, such as operational versatility of the devices, are scrutinized in terms of their analytical efficacy. It is found that due to multi-functionality capability of modern microfluidics, there is big amount of experimental data obtainable from a single device, allowing complex experimental control and efficient data correlation, particularly important when biomedical studies are considered. Hence several examples on cell culture and monitoring are given in this review, including details on design of microfluidic devices with their distinctive technological peculiarities.

Original language	English (US)
Pages (from-to)	14-28
Number of pages	15
Journal	Microelectronic Engineering
Volume	208
DOIs	https://doi.org/10.1016/j.mee.2019.01.004
State	Published - Jan 28 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the project for Young researchers financed from the Italian Ministry of Health “High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices” (CUP J65C13001350001, project No. GR-2010-2311677) granted to the nanotechnology laboratory of the Department of Experimental and Clinical Medicine of the University “Magna Graecia” of Catanzaro.

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10.1016/j.mee.2019.01.004

https://repository.kaust.edu.sa/bitstream/10754/631136/1/1-s2.0-S016793171930019X-main.pdf

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@article{19483f556452447f9deadaef9f09b194,

title = "Microfluidic platforms for cell cultures and investigations",

abstract = "This review covers several aspects of microfluidic devices used for culturing and monitoring of both adherent and non-adherent cells, including a multitude of applications. A comparison of available platforms with high throughput analysis, automation capability, interface to sensors and integration, is reported. Aspects, such as operational versatility of the devices, are scrutinized in terms of their analytical efficacy. It is found that due to multi-functionality capability of modern microfluidics, there is big amount of experimental data obtainable from a single device, allowing complex experimental control and efficient data correlation, particularly important when biomedical studies are considered. Hence several examples on cell culture and monitoring are given in this review, including details on design of microfluidic devices with their distinctive technological peculiarities.",

author = "Coluccio, {Maria Laura} and Gerardo Perozziello and Natalia Malara and Elvira Parrotta and Peng Zhang and Francesco Gentile and Tania Limongi and Raj, {Pushparani Michael} and Gianni Cuda and Patrizio Candeloro and {Di Fabrizio}, {Enzo M.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by the project for Young researchers financed from the Italian Ministry of Health “High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices” (CUP J65C13001350001, project No. GR-2010-2311677) granted to the nanotechnology laboratory of the Department of Experimental and Clinical Medicine of the University “Magna Graecia” of Catanzaro.",

year = "2019",

month = jan,

day = "28",

doi = "10.1016/j.mee.2019.01.004",

language = "English (US)",

volume = "208",

pages = "14--28",

journal = "Microelectronic Engineering",

issn = "0167-9317",

publisher = "Elsevier B.V.",

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T1 - Microfluidic platforms for cell cultures and investigations

AU - Coluccio, Maria Laura

AU - Perozziello, Gerardo

AU - Malara, Natalia

AU - Parrotta, Elvira

AU - Zhang, Peng

AU - Gentile, Francesco

AU - Limongi, Tania

AU - Raj, Pushparani Michael

AU - Cuda, Gianni

AU - Candeloro, Patrizio

AU - Di Fabrizio, Enzo M.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This work was supported by the project for Young researchers financed from the Italian Ministry of Health “High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices” (CUP J65C13001350001, project No. GR-2010-2311677) granted to the nanotechnology laboratory of the Department of Experimental and Clinical Medicine of the University “Magna Graecia” of Catanzaro.

PY - 2019/1/28

Y1 - 2019/1/28

N2 - This review covers several aspects of microfluidic devices used for culturing and monitoring of both adherent and non-adherent cells, including a multitude of applications. A comparison of available platforms with high throughput analysis, automation capability, interface to sensors and integration, is reported. Aspects, such as operational versatility of the devices, are scrutinized in terms of their analytical efficacy. It is found that due to multi-functionality capability of modern microfluidics, there is big amount of experimental data obtainable from a single device, allowing complex experimental control and efficient data correlation, particularly important when biomedical studies are considered. Hence several examples on cell culture and monitoring are given in this review, including details on design of microfluidic devices with their distinctive technological peculiarities.

AB - This review covers several aspects of microfluidic devices used for culturing and monitoring of both adherent and non-adherent cells, including a multitude of applications. A comparison of available platforms with high throughput analysis, automation capability, interface to sensors and integration, is reported. Aspects, such as operational versatility of the devices, are scrutinized in terms of their analytical efficacy. It is found that due to multi-functionality capability of modern microfluidics, there is big amount of experimental data obtainable from a single device, allowing complex experimental control and efficient data correlation, particularly important when biomedical studies are considered. Hence several examples on cell culture and monitoring are given in this review, including details on design of microfluidic devices with their distinctive technological peculiarities.

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DO - 10.1016/j.mee.2019.01.004

M3 - Article

SN - 0167-9317

VL - 208

SP - 14

EP - 28

JO - Microelectronic Engineering

JF - Microelectronic Engineering

ER -

Microfluidic platforms for cell cultures and investigations

Abstract

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