The development of hydrogen sulfide (H2S) sensors is essential to address H2S-related pharmacology since slow-releasing H2S medications have been identified to be prospective options for cancer treatments. Here, we described an electrochemical sensor for highly selective and sensitive detection of aqueous H2S, using a thin film of fumarate-based face-centered cubic (fcu)-based metal–organic frameworks (fum-fcu-MOF) modified on laser-scribed graphene (LSGE). The fum-fcu-MOF has shown a strong affinity and chemical stability to H2S analysis. The electrochemical and H2S catalytic properties were studied for fum-fcu-MOF/LSGE. An amperometry and differential pulse voltammetry techniques were demonstrated to validate the sensor. The resulting sensor delivered acceptable analytical parameters in terms of; detection limit (3.0 µM), dynamic range (10–500 µM), reproducibility, and stability (94.7%). The sensor's practical validity was demonstrated in bacterial cells and H2S-releasing drug, where the sensor was able to monitor the continuous release of in-situ H2S. The pharmacokinetics of a slow releasing H2S donor is accessed at different time intervals and different concentration levels. Our research indicate that this fum-fcu-MOF based H2S sensor holds potential in understanding pharmacokinetics of H2S releasing drugs.
Bibliographical noteKAUST Repository Item: Exported on 2023-08-31
Acknowledgements: This work was supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia. In addition, we acknowledge the funding from the KAUST smart health initiative.