Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides

Marta Cal; Aleksandra Kotynia; Lukasz Jaremko; Mariusz Jaremko; Marek Lisowski; Małgorzata Cebo; Justyna Brasuń; Piotr Stefanowicz

doi:10.1039/c5dt01267h

Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides

Marta Cal, Aleksandra Kotynia, Lukasz Jaremko, Mariusz Jaremko, Marek Lisowski, Małgorzata Cebo, Justyna Brasuń, Piotr Stefanowicz^*

^*Corresponding author for this work

Biological, Environmental Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

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Abstract

Self-assembly is a widely studied, spontaneous, and reversible phenomenon leading to the formation of the ordered structures by non-covalent specific interactions among starting molecules. In this work, a new template for the self-assembly of polypeptides based on peptides containing the C-terminal histidinehydroxamic acid moiety and Cu²⁺ ions is characterized. Two peptide (tripeptide and pentadecapeptide) hydroxamic acid systems were synthesized and their interactions with Cu²⁺ ions were investigated, revealing a high stability of the supramolecular assemblies formed. The supramolecular metallacrown-based L₄Cu₅ complexes exist at physiological pH in the presence of Cu²⁺ ions as is evidenced from the spectroscopic methods, ESI mass spectrometry, and physicochemical techniques.

Original language	English (US)
Pages (from-to)	11172-11181
Number of pages	10
Journal	Dalton transactions
Volume	44
Issue number	24
DOIs	https://doi.org/10.1039/c5dt01267h
State	Published - Jun 28 2015

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© The Royal Society of Chemistry.

ASJC Scopus subject areas

Inorganic Chemistry

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title = "Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides",

abstract = "Self-assembly is a widely studied, spontaneous, and reversible phenomenon leading to the formation of the ordered structures by non-covalent specific interactions among starting molecules. In this work, a new template for the self-assembly of polypeptides based on peptides containing the C-terminal histidinehydroxamic acid moiety and Cu2+ ions is characterized. Two peptide (tripeptide and pentadecapeptide) hydroxamic acid systems were synthesized and their interactions with Cu2+ ions were investigated, revealing a high stability of the supramolecular assemblies formed. The supramolecular metallacrown-based L4Cu5 complexes exist at physiological pH in the presence of Cu2+ ions as is evidenced from the spectroscopic methods, ESI mass spectrometry, and physicochemical techniques.",

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doi = "10.1039/c5dt01267h",

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T1 - Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides

AU - Cal, Marta

AU - Kotynia, Aleksandra

AU - Jaremko, Lukasz

AU - Jaremko, Mariusz

AU - Lisowski, Marek

AU - Cebo, Małgorzata

AU - Brasuń, Justyna

AU - Stefanowicz, Piotr

PY - 2015/6/28

Y1 - 2015/6/28

N2 - Self-assembly is a widely studied, spontaneous, and reversible phenomenon leading to the formation of the ordered structures by non-covalent specific interactions among starting molecules. In this work, a new template for the self-assembly of polypeptides based on peptides containing the C-terminal histidinehydroxamic acid moiety and Cu2+ ions is characterized. Two peptide (tripeptide and pentadecapeptide) hydroxamic acid systems were synthesized and their interactions with Cu2+ ions were investigated, revealing a high stability of the supramolecular assemblies formed. The supramolecular metallacrown-based L4Cu5 complexes exist at physiological pH in the presence of Cu2+ ions as is evidenced from the spectroscopic methods, ESI mass spectrometry, and physicochemical techniques.

AB - Self-assembly is a widely studied, spontaneous, and reversible phenomenon leading to the formation of the ordered structures by non-covalent specific interactions among starting molecules. In this work, a new template for the self-assembly of polypeptides based on peptides containing the C-terminal histidinehydroxamic acid moiety and Cu2+ ions is characterized. Two peptide (tripeptide and pentadecapeptide) hydroxamic acid systems were synthesized and their interactions with Cu2+ ions were investigated, revealing a high stability of the supramolecular assemblies formed. The supramolecular metallacrown-based L4Cu5 complexes exist at physiological pH in the presence of Cu2+ ions as is evidenced from the spectroscopic methods, ESI mass spectrometry, and physicochemical techniques.

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DO - 10.1039/c5dt01267h

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SN - 1477-9226

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JF - Dalton transactions

IS - 24

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Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides

Abstract

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