Metal-Organic Frameworks Meet Molecularly Imprinted Polymers: Insights and Prospects for Sensor Applications

Abdellatif Ait Lahcen, Sandeep G. Surya, Tutku Beduk, Mani Teja Vijjapu, Abderrahman Lamaoui, Ceren Durmus, Suna Timur, Osama Shekhah, Veerappan Mani, Aziz Amine*, Mohamed Eddaoudi*, Khaled Nabil Salama*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


The use of porous materials as the core for synthesizing molecularly imprinted polymers (MIPs) adds significant value to the resulting sensing system. This review covers in detail the current progress and achievements regarding the synergistic combination of MIPs and porous materials, namely metal/covalent-organic frameworks (MOFs/COFs), including the application of such frameworks in the development of upgraded sensor platforms. The different processes involved in the synthesis of MOF/COF-MIPs are outlined, along with their intrinsic properties. Special attention is paid to debriefing the impact of the morphological changes that occur through the synergistic combination compared to those that occur due to the individual entities. Thereafter, the strategies used for building the sensors, as well as the transduction modes, are overviewed and discussed. This is followed by a full description of research advances for various types of MOF/COF-MIP-based (bio)sensors and their applications in the fields of environmental monitoring, food safety, and pharmaceutical analysis. Finally, the challenges/drawbacks, as well as the prospects of this research field, are discussed in detail.

Original languageEnglish (US)
JournalACS Applied Materials and Interfaces
StateAccepted/In press - 2022

Bibliographical note

Funding Information:
The authors would like to acknowledge the financial support in the form of funding from King Abdullah University of Science and Technology (KAUST), Saudi Arabia. Furthermore, we thank the KAUST Sensor Initiative and KAUST visiting student program for supporting this work.

Publisher Copyright:
© 2022 The Authors. Published by American Chemical Society.


  • biosensors
  • chemical sensors
  • covalent-organic frameworks
  • metal-organic frameworks
  • molecularly imprinted polymers
  • solid-phase extraction

ASJC Scopus subject areas

  • General Materials Science


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