Metal-Organic Framework Capillary Microreactor for Application in Click Chemistry

Lara A. Truter; Jana Juan-Alcañiz; Freek Kapteijn; Tjeerd A. Nijhuis; Jorge Gascon; Jaap C. Schouten

doi:10.1002/cctc.201600016

Metal-Organic Framework Capillary Microreactor for Application in Click Chemistry

Lara A. Truter, Jana Juan-Alcañiz, Freek Kapteijn, Tjeerd A. Nijhuis, Jorge Gascon^*, Jaap C. Schouten

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A Cu/PMA-MIL-101(Cr) metal-organic-framework-coated microreactor has been applied in the 1,3-dipolar cycloaddition of benzyl azide and phenylactetylene (click chemistry). The Cu/PMA-MIL-101(Cr) catalyst was incorporated by using a washcoating method. The use of tetraethylorthosilicate (TEOS) and a copolymer pluronic F127 as binders resulted in a stable and uniform coating of 6 μm. The application of the Cu/PMA-MIL-101(Cr) capillary microreactor in the click-chemistry reaction resulted in a similar intrinsic activity as in the batch reactor, and a continuous production for more than 150 h time-on-stream could be achieved. The presence of water in the reagent feed led to reversible catalyst deactivation and was necessary to be removed to obtain a stable catalyst operation.

Original language	English (US)
Pages (from-to)	1692-1698
Number of pages	7
Journal	ChemCatChem
Volume	8
Issue number	9
DOIs	https://doi.org/10.1002/cctc.201600016
State	Published - May 9 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

click chemistry
copper
mesoporous materials
metal-organic frameworks
microreactors

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1002/cctc.201600016

Cite this

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title = "Metal-Organic Framework Capillary Microreactor for Application in Click Chemistry",

abstract = "A Cu/PMA-MIL-101(Cr) metal-organic-framework-coated microreactor has been applied in the 1,3-dipolar cycloaddition of benzyl azide and phenylactetylene (click chemistry). The Cu/PMA-MIL-101(Cr) catalyst was incorporated by using a washcoating method. The use of tetraethylorthosilicate (TEOS) and a copolymer pluronic F127 as binders resulted in a stable and uniform coating of 6 μm. The application of the Cu/PMA-MIL-101(Cr) capillary microreactor in the click-chemistry reaction resulted in a similar intrinsic activity as in the batch reactor, and a continuous production for more than 150 h time-on-stream could be achieved. The presence of water in the reagent feed led to reversible catalyst deactivation and was necessary to be removed to obtain a stable catalyst operation.",

keywords = "click chemistry, copper, mesoporous materials, metal-organic frameworks, microreactors",

author = "Truter, {Lara A.} and Jana Juan-Alca{\~n}iz and Freek Kapteijn and Nijhuis, {Tjeerd A.} and Jorge Gascon and Schouten, {Jaap C.}",

note = "Publisher Copyright: {\textcopyright} 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2016",

month = may,

day = "9",

doi = "10.1002/cctc.201600016",

language = "English (US)",

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T1 - Metal-Organic Framework Capillary Microreactor for Application in Click Chemistry

AU - Truter, Lara A.

AU - Juan-Alcañiz, Jana

AU - Kapteijn, Freek

AU - Nijhuis, Tjeerd A.

AU - Gascon, Jorge

AU - Schouten, Jaap C.

PY - 2016/5/9

Y1 - 2016/5/9

N2 - A Cu/PMA-MIL-101(Cr) metal-organic-framework-coated microreactor has been applied in the 1,3-dipolar cycloaddition of benzyl azide and phenylactetylene (click chemistry). The Cu/PMA-MIL-101(Cr) catalyst was incorporated by using a washcoating method. The use of tetraethylorthosilicate (TEOS) and a copolymer pluronic F127 as binders resulted in a stable and uniform coating of 6 μm. The application of the Cu/PMA-MIL-101(Cr) capillary microreactor in the click-chemistry reaction resulted in a similar intrinsic activity as in the batch reactor, and a continuous production for more than 150 h time-on-stream could be achieved. The presence of water in the reagent feed led to reversible catalyst deactivation and was necessary to be removed to obtain a stable catalyst operation.

AB - A Cu/PMA-MIL-101(Cr) metal-organic-framework-coated microreactor has been applied in the 1,3-dipolar cycloaddition of benzyl azide and phenylactetylene (click chemistry). The Cu/PMA-MIL-101(Cr) catalyst was incorporated by using a washcoating method. The use of tetraethylorthosilicate (TEOS) and a copolymer pluronic F127 as binders resulted in a stable and uniform coating of 6 μm. The application of the Cu/PMA-MIL-101(Cr) capillary microreactor in the click-chemistry reaction resulted in a similar intrinsic activity as in the batch reactor, and a continuous production for more than 150 h time-on-stream could be achieved. The presence of water in the reagent feed led to reversible catalyst deactivation and was necessary to be removed to obtain a stable catalyst operation.

KW - click chemistry

KW - copper

KW - mesoporous materials

KW - metal-organic frameworks

KW - microreactors

UR - http://www.scopus.com/inward/record.url?scp=84979725217&partnerID=8YFLogxK

U2 - 10.1002/cctc.201600016

DO - 10.1002/cctc.201600016

M3 - Article

AN - SCOPUS:84979725217

SN - 1867-3880

VL - 8

SP - 1692

EP - 1698

JO - ChemCatChem

JF - ChemCatChem

IS - 9

ER -

Metal-Organic Framework Capillary Microreactor for Application in Click Chemistry

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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