Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones

Min Ye, Yuelu Wen, Huifang Li, Yejuan Fu, Qinghao Wang

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


A highly regioselective and efficient metal-free hydration of aromatic haloalkynes to alpha-halomethyl ketones using cheap tetrafluoroboric acid as catalyst is described. The protocol is conducted under convenient conditions and affords products in good to excellent yields, with broad substrate scope, including a variety of aromatic alkynyl chlorides, alkynyl bromides, and alkynyl iodides. (C) 2016 Elsevier Ltd. All rights reserved.
Original languageEnglish (US)
Pages (from-to)4983-4986
Number of pages4
JournalTetrahedron Letters
Issue number45
StatePublished - Oct 1 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The authors thank the NSFC (21202023) and the NSF of Jiangxi Provincial Education Department (GJJ151005 and GJJ14656) for financial support.


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