A highly regioselective and efficient metal-free hydration of aromatic haloalkynes to alpha-halomethyl ketones using cheap tetrafluoroboric acid as catalyst is described. The protocol is conducted under convenient conditions and affords products in good to excellent yields, with broad substrate scope, including a variety of aromatic alkynyl chlorides, alkynyl bromides, and alkynyl iodides. (C) 2016 Elsevier Ltd. All rights reserved.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Oct 1 2016|
Bibliographical noteKAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The authors thank the NSFC (21202023) and the NSF of Jiangxi Provincial Education Department (GJJ151005 and GJJ14656) for financial support.