Metal Enhanced Fluorescence on Super-Hydrophobic Clusters of Gold Nanoparticles

Edmondo Battista, Maria Laura Coluccio, Alessandro Alabastri, Marianna Barberio, Filippo Causa, Paolo Antonio Netti, Enzo M. Di Fabrizio, Francesco Gentile

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We used optical lithography, electroless deposition and deep reactive ion etching techniques to realize arrays of super-hydrophobic gold nanoparticles arranged in a hierarchical structure. At the micro-scale, silicon-micro pillars in the chip permit to manipulate and concentrate biological solutions, at the nano-scale, gold nanoparticles enable metal enhanced fluorescence (MEF) effects, whereby fluorescence signal of fluorophores in close proximity to a rough metal surface is amplified by orders of magnitude. Here, we demonstrated the device in the analysis of fluorescein derived gold-binding peptides (GBP-FITC). While super-hydrophobic schemes and MEF effects have been heretofore used in isolation, their integration in a platform may advance the current state of fluorescence-based sensing technology in medical diagnostics and biotechnology. This scheme may be employed in protein microarrays where the increased sensitivity of the device may enable the early detection of cancer biomarkers or other proteins of biomedical interest.
Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalMicroelectronic Engineering
StatePublished - Dec 15 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work has been partially funded from the Italian Minister of Health (Project n. GR-2010-2320665) and by UE, MIUR and Ministero dello Sviluppo Economico (project ITEM (Infrastruttura per Tecnologie BioMEMS di Sensing Avanzato per Monitoraggio e Diagnostica Ambientale e Alimentare) PONa3_00077).


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