Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis

Qingtian Guan, Bushra Alhuthali, Sara Mfarrej, Magid Abdel Halim, Reem S Almaghrabi, Arnab Pain

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We identified Naegleria fowleri as the aetiologic agent from cerebrospinal fluid (CSF) of a patient with a travel history to Karachi. We demonstrate the benefit of metagenomics-based rapid diagnosis of primary amoebic meningoencephalitis (PAM) when routine clinical tests fail to provide a definitive diagnosis. We reconstructed the N. fowleri genome.
Original languageEnglish (US)
JournalJournal of Travel Medicine
StatePublished - Nov 5 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-11-13
Acknowledged KAUST grant number(s): BAS/1/1020-01- 01, REI/1/4468-01-01]
Acknowledgements: This work was supported by King Abdullah University of Science and Technology Smart Health Initiative fund [REI/1/4468-01-01] to A.P. and R.S.A. and a KAUST faculty baseline fund [BAS/1/1020-01- 01] AP.

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health


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