Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis

Qingtian Guan; Bushra Alhuthali; Sara Mfarrej; Magid Abdel Halim; Reem S Almaghrabi; Arnab Pain

doi:10.1093/jtm/taab172

Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis

Qingtian Guan, Bushra Alhuthali, Sara Mfarrej, Magid Abdel Halim, Reem S Almaghrabi, Arnab Pain

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We identified Naegleria fowleri as the aetiologic agent from cerebrospinal fluid (CSF) of a patient with a travel history to Karachi. We demonstrate the benefit of metagenomics-based rapid diagnosis of primary amoebic meningoencephalitis (PAM) when routine clinical tests fail to provide a definitive diagnosis. We reconstructed the N. fowleri genome.

Original language	English (US)
Journal	Journal of Travel Medicine
DOIs	https://doi.org/10.1093/jtm/taab172
State	Published - Nov 5 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-11-13
Acknowledged KAUST grant number(s): BAS/1/1020-01- 01, REI/1/4468-01-01]
Acknowledgements: This work was supported by King Abdullah University of Science and Technology Smart Health Initiative fund [REI/1/4468-01-01] to A.P. and R.S.A. and a KAUST faculty baseline fund [BAS/1/1020-01- 01] AP.

ASJC Scopus subject areas

Infectious Diseases
Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jtm/taab172

https://repository.kaust.edu.sa/bitstream/10754/673327/1/taab172.pdf

Cite this

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title = "Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis",

abstract = "We identified Naegleria fowleri as the aetiologic agent from cerebrospinal fluid (CSF) of a patient with a travel history to Karachi. We demonstrate the benefit of metagenomics-based rapid diagnosis of primary amoebic meningoencephalitis (PAM) when routine clinical tests fail to provide a definitive diagnosis. We reconstructed the N. fowleri genome.",

author = "Qingtian Guan and Bushra Alhuthali and Sara Mfarrej and Halim, {Magid Abdel} and Almaghrabi, {Reem S} and Arnab Pain",

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doi = "10.1093/jtm/taab172",

language = "English (US)",

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AU - Guan, Qingtian

AU - Alhuthali, Bushra

AU - Mfarrej, Sara

AU - Halim, Magid Abdel

AU - Almaghrabi, Reem S

AU - Pain, Arnab

N1 - KAUST Repository Item: Exported on 2021-11-13 Acknowledged KAUST grant number(s): BAS/1/1020-01- 01, REI/1/4468-01-01] Acknowledgements: This work was supported by King Abdullah University of Science and Technology Smart Health Initiative fund [REI/1/4468-01-01] to A.P. and R.S.A. and a KAUST faculty baseline fund [BAS/1/1020-01- 01] AP.

PY - 2021/11/5

Y1 - 2021/11/5

N2 - We identified Naegleria fowleri as the aetiologic agent from cerebrospinal fluid (CSF) of a patient with a travel history to Karachi. We demonstrate the benefit of metagenomics-based rapid diagnosis of primary amoebic meningoencephalitis (PAM) when routine clinical tests fail to provide a definitive diagnosis. We reconstructed the N. fowleri genome.

AB - We identified Naegleria fowleri as the aetiologic agent from cerebrospinal fluid (CSF) of a patient with a travel history to Karachi. We demonstrate the benefit of metagenomics-based rapid diagnosis of primary amoebic meningoencephalitis (PAM) when routine clinical tests fail to provide a definitive diagnosis. We reconstructed the N. fowleri genome.

UR - http://hdl.handle.net/10754/673327

UR - https://academic.oup.com/jtm/advance-article/doi/10.1093/jtm/taab172/6420899

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DO - 10.1093/jtm/taab172

M3 - Article

C2 - 34738616

SN - 1195-1982

JO - Journal of Travel Medicine

JF - Journal of Travel Medicine

ER -

Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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