Merging Iron Catalysis and Biocatalysis-Iron Carbonyl Complexes as Efficient Hydrogen Autotransfer Catalysts in Dynamic Kinetic Resolutions

Osama El-Sepelgy; Nurtalya Alandini; Magnus Rueping

doi:10.1002/anie.201606197

Merging Iron Catalysis and Biocatalysis-Iron Carbonyl Complexes as Efficient Hydrogen Autotransfer Catalysts in Dynamic Kinetic Resolutions

Osama El-Sepelgy, Nurtalya Alandini, Magnus Rueping

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

A dual catalytic iron/lipase system has been developed and applied in the dynamic kinetic resolution of benzylic and aliphatic secondary alcohols. A detailed study of the Knölker-type iron complexes demonstrated the hydrogen autotransfer of alcohols to proceed under mild reaction conditions and allowed the combination with the enzymatic resolution. Different racemic alcohols were efficiently converted to chiral acetates in good yields and with excellent enantioselectivities. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Original language	English (US)
Pages (from-to)	13602-13605
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	55
Issue number	43
DOIs	https://doi.org/10.1002/anie.201606197 https://doi.org/10.1002/ange.201606197
State	Published - Sep 29 2016

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KAUST Repository Item: Exported on 2020-10-01

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AU - Rueping, Magnus

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AB - A dual catalytic iron/lipase system has been developed and applied in the dynamic kinetic resolution of benzylic and aliphatic secondary alcohols. A detailed study of the Knölker-type iron complexes demonstrated the hydrogen autotransfer of alcohols to proceed under mild reaction conditions and allowed the combination with the enzymatic resolution. Different racemic alcohols were efficiently converted to chiral acetates in good yields and with excellent enantioselectivities. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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UR - http://onlinelibrary.wiley.com/doi/10.1002/anie.201606197/abstract

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JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 43

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Merging Iron Catalysis and Biocatalysis-Iron Carbonyl Complexes as Efficient Hydrogen Autotransfer Catalysts in Dynamic Kinetic Resolutions

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