(Chemical Equation Presented) A powerful engine: The Cu-catalyzed azide-alkyne cycloaddition depends on rapid formation of CuI- acetylide complexes from terminal alkynes 2 and their ability to activate organic azides 1. A kinetics study uncovered a bimolecular dependence on the metal and an unusually fast intramolecular variant of the process. The results suggest the importance of 3 as a reactive intermediate.
|Original language||English (US)|
|Number of pages||6|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Apr 8 2005|
- Click chemistry
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