Measurement of lung expansion with computed tomography and comparison with quantitative histology

H. O. Coxson; J. R. Mayo; H. Behzad; B. J. Moore; L. M. Verburgt; C. A. Staples; P. D. Pare; J. C. Hogg

doi:10.1152/jappl.1995.79.5.1525

Measurement of lung expansion with computed tomography and comparison with quantitative histology

H. O. Coxson, J. R. Mayo, H. Behzad, B. J. Moore, L. M. Verburgt, C. A. Staples, P. D. Pare, J. C. Hogg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

The total and regional lung volumes were estimated from computed tomography (CT), and the pleural pressure gradient was determined by using the milliliters of gas per gram of tissue estimated from the X-ray attenuation values and the pressure-volume curve of the lung. The data show that CT accurately estimated the volume of the resected lobe but overestimated its weight by 24 ± 19%. The volume of gas per gram of tissue was less in the gravity-dependent regions due to a pleural pressure gradient of 0.24 ± 0.08 cmH₂O/cm of descent in the thorax. The proportion of tissue to air obtained with CT was similar to that obtained by quantitative histology. We conclude that the CT scan can be used to estimate total and regional lung volumes and that measurements of the proportions of tissue and air within the thorax by CT can be used in conjunction with quantitative histology to evaluate lung structure.

Original language	English (US)
Pages (from-to)	1525-1530
Number of pages	6
Journal	Journal of Applied Physiology
Volume	79
Issue number	5
DOIs	https://doi.org/10.1152/jappl.1995.79.5.1525
State	Published - 1995
Externally published	Yes

Keywords

pulmonary physiology
stereology

ASJC Scopus subject areas

Physiology
Physiology (medical)

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10.1152/jappl.1995.79.5.1525

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title = "Measurement of lung expansion with computed tomography and comparison with quantitative histology",

abstract = "The total and regional lung volumes were estimated from computed tomography (CT), and the pleural pressure gradient was determined by using the milliliters of gas per gram of tissue estimated from the X-ray attenuation values and the pressure-volume curve of the lung. The data show that CT accurately estimated the volume of the resected lobe but overestimated its weight by 24 ± 19%. The volume of gas per gram of tissue was less in the gravity-dependent regions due to a pleural pressure gradient of 0.24 ± 0.08 cmH2O/cm of descent in the thorax. The proportion of tissue to air obtained with CT was similar to that obtained by quantitative histology. We conclude that the CT scan can be used to estimate total and regional lung volumes and that measurements of the proportions of tissue and air within the thorax by CT can be used in conjunction with quantitative histology to evaluate lung structure.",

keywords = "pulmonary physiology, stereology",

author = "Coxson, {H. O.} and Mayo, {J. R.} and H. Behzad and Moore, {B. J.} and Verburgt, {L. M.} and Staples, {C. A.} and Pare, {P. D.} and Hogg, {J. C.}",

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T1 - Measurement of lung expansion with computed tomography and comparison with quantitative histology

AU - Coxson, H. O.

AU - Mayo, J. R.

AU - Behzad, H.

AU - Moore, B. J.

AU - Verburgt, L. M.

AU - Staples, C. A.

AU - Pare, P. D.

AU - Hogg, J. C.

PY - 1995

Y1 - 1995

N2 - The total and regional lung volumes were estimated from computed tomography (CT), and the pleural pressure gradient was determined by using the milliliters of gas per gram of tissue estimated from the X-ray attenuation values and the pressure-volume curve of the lung. The data show that CT accurately estimated the volume of the resected lobe but overestimated its weight by 24 ± 19%. The volume of gas per gram of tissue was less in the gravity-dependent regions due to a pleural pressure gradient of 0.24 ± 0.08 cmH2O/cm of descent in the thorax. The proportion of tissue to air obtained with CT was similar to that obtained by quantitative histology. We conclude that the CT scan can be used to estimate total and regional lung volumes and that measurements of the proportions of tissue and air within the thorax by CT can be used in conjunction with quantitative histology to evaluate lung structure.

AB - The total and regional lung volumes were estimated from computed tomography (CT), and the pleural pressure gradient was determined by using the milliliters of gas per gram of tissue estimated from the X-ray attenuation values and the pressure-volume curve of the lung. The data show that CT accurately estimated the volume of the resected lobe but overestimated its weight by 24 ± 19%. The volume of gas per gram of tissue was less in the gravity-dependent regions due to a pleural pressure gradient of 0.24 ± 0.08 cmH2O/cm of descent in the thorax. The proportion of tissue to air obtained with CT was similar to that obtained by quantitative histology. We conclude that the CT scan can be used to estimate total and regional lung volumes and that measurements of the proportions of tissue and air within the thorax by CT can be used in conjunction with quantitative histology to evaluate lung structure.

KW - pulmonary physiology

KW - stereology

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JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

IS - 5

ER -

Measurement of lung expansion with computed tomography and comparison with quantitative histology

Abstract

Keywords

ASJC Scopus subject areas

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