McClintock's challenge in the 21st century

Nina V. Fedoroff

doi:10.1073/pnas.1215482109

McClintock's challenge in the 21st century

Nina V. Fedoroff

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

In 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she identified. McClintock described the suite of nuclear events, including transposon activation and various chromosome aberrations and rearrangements, that unfolded in the wake of genetic crosses that brought together two broken chromosomes 9. McClintock left future generations with the challenge of understanding how genomes respond to genetic and environmental stresses by mounting adaptive responses that frequently include genome restructuring.

Original language	English (US)
Pages (from-to)	20200-20203
Number of pages	4
Journal	Proceedings of the National Academy of Sciences
Volume	109
Issue number	50
DOIs	https://doi.org/10.1073/pnas.1215482109
State	Published - Nov 13 2012

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KAUST Repository Item: Exported on 2020-10-01

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AB - In 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she identified. McClintock described the suite of nuclear events, including transposon activation and various chromosome aberrations and rearrangements, that unfolded in the wake of genetic crosses that brought together two broken chromosomes 9. McClintock left future generations with the challenge of understanding how genomes respond to genetic and environmental stresses by mounting adaptive responses that frequently include genome restructuring.

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McClintock's challenge in the 21st century

Abstract

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