MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity

David Latrasse; Teddy Jégu; Huchen Li; Axel de Zélicourt; Cécile Raynaud; Stéphanie Legras; Andrea Gust; Olga Samajova; Alaguraj Veluchamy; Naganand Rayapuram; Juan Sebastian Ramirez Prado; Olga Kulikova; Jean Colcombet; Jean Bigeard; Baptiste Genot; Ton Bisseling; Moussa Benhamed; Heribert Hirt

doi:10.1186/s13059-017-1261-8

MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity

David Latrasse, Teddy Jégu, Huchen Li, Axel de Zélicourt, Cécile Raynaud, Stéphanie Legras, Andrea Gust, Olga Samajova, Alaguraj Veluchamy, Naganand Rayapuram, Juan Sebastian Ramirez Prado, Olga Kulikova, Jean Colcombet, Jean Bigeard, Baptiste Genot, Ton Bisseling, Moussa Benhamed, Heribert Hirt

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69 Scopus citations

Abstract

Microbial-associated molecular patterns activate several MAP kinases, which are major regulators of the innate immune response in Arabidopsis thaliana that induce large-scale changes in gene expression. Here, we determine whether microbial-associated molecular pattern-triggered gene expression involves modifications at the chromatin level.Histone acetylation and deacetylation are major regulators of microbial-associated molecular pattern-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defence gene expression and innate immunity. The MAP kinase MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase.By studying a number of gene loci that undergo microbial-associated molecular pattern-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.

Original language	English (US)
Journal	Genome biology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s13059-017-1261-8
State	Published - Jul 6 2017

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): CRG4
Acknowledgements: Funding for the project was provided to HH and MB by a grant of the French National Agency of Research (LabEx Saclay Plant Sciences-SPS ANR-10-LABX-0040-SPS) as well as by grant CRG4 of the King Abdullah University of Science and Technology. Moreover, OS was supported by the Czech Science Foundation GA ČR grant no. GA16-22044S. No ethics approval was required for this project.

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10.1186/s13059-017-1261-8

https://repository.kaust.edu.sa/bitstream/10754/625224/1/document.pdf

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Latrasse, D., Jégu, T., Li, H., Zélicourt, A. D., Raynaud, C., Legras, S., Gust, A., Samajova, O., Veluchamy, A., Rayapuram, N., Ramirez Prado, J. S., Kulikova, O., Colcombet, J., Bigeard, J., Genot, B., Bisseling, T., Benhamed, M., & Hirt, H. (2017). MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity. Genome biology, 18(1). https://doi.org/10.1186/s13059-017-1261-8

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title = "MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity",

abstract = "Microbial-associated molecular patterns activate several MAP kinases, which are major regulators of the innate immune response in Arabidopsis thaliana that induce large-scale changes in gene expression. Here, we determine whether microbial-associated molecular pattern-triggered gene expression involves modifications at the chromatin level.Histone acetylation and deacetylation are major regulators of microbial-associated molecular pattern-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defence gene expression and innate immunity. The MAP kinase MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase.By studying a number of gene loci that undergo microbial-associated molecular pattern-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.",

author = "David Latrasse and Teddy J{\'e}gu and Huchen Li and Z{\'e}licourt, {Axel de} and C{\'e}cile Raynaud and St{\'e}phanie Legras and Andrea Gust and Olga Samajova and Alaguraj Veluchamy and Naganand Rayapuram and {Ramirez Prado}, {Juan Sebastian} and Olga Kulikova and Jean Colcombet and Jean Bigeard and Baptiste Genot and Ton Bisseling and Moussa Benhamed and Heribert Hirt",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): CRG4 Acknowledgements: Funding for the project was provided to HH and MB by a grant of the French National Agency of Research (LabEx Saclay Plant Sciences-SPS ANR-10-LABX-0040-SPS) as well as by grant CRG4 of the King Abdullah University of Science and Technology. Moreover, OS was supported by the Czech Science Foundation GA {\v C}R grant no. GA16-22044S. No ethics approval was required for this project.",

year = "2017",

month = jul,

day = "6",

doi = "10.1186/s13059-017-1261-8",

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Latrasse, D, Jégu, T, Li, H, Zélicourt, AD, Raynaud, C, Legras, S, Gust, A, Samajova, O, Veluchamy, A, Rayapuram, N, Ramirez Prado, JS, Kulikova, O, Colcombet, J, Bigeard, J, Genot, B, Bisseling, T, Benhamed, M & Hirt, H 2017, 'MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity', Genome biology, vol. 18, no. 1. https://doi.org/10.1186/s13059-017-1261-8

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T1 - MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity

AU - Latrasse, David

AU - Jégu, Teddy

AU - Li, Huchen

AU - Zélicourt, Axel de

AU - Raynaud, Cécile

AU - Legras, Stéphanie

AU - Gust, Andrea

AU - Samajova, Olga

AU - Veluchamy, Alaguraj

AU - Rayapuram, Naganand

AU - Ramirez Prado, Juan Sebastian

AU - Kulikova, Olga

AU - Colcombet, Jean

AU - Bigeard, Jean

AU - Genot, Baptiste

AU - Bisseling, Ton

AU - Benhamed, Moussa

AU - Hirt, Heribert

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): CRG4 Acknowledgements: Funding for the project was provided to HH and MB by a grant of the French National Agency of Research (LabEx Saclay Plant Sciences-SPS ANR-10-LABX-0040-SPS) as well as by grant CRG4 of the King Abdullah University of Science and Technology. Moreover, OS was supported by the Czech Science Foundation GA ČR grant no. GA16-22044S. No ethics approval was required for this project.

PY - 2017/7/6

Y1 - 2017/7/6

N2 - Microbial-associated molecular patterns activate several MAP kinases, which are major regulators of the innate immune response in Arabidopsis thaliana that induce large-scale changes in gene expression. Here, we determine whether microbial-associated molecular pattern-triggered gene expression involves modifications at the chromatin level.Histone acetylation and deacetylation are major regulators of microbial-associated molecular pattern-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defence gene expression and innate immunity. The MAP kinase MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase.By studying a number of gene loci that undergo microbial-associated molecular pattern-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.

AB - Microbial-associated molecular patterns activate several MAP kinases, which are major regulators of the innate immune response in Arabidopsis thaliana that induce large-scale changes in gene expression. Here, we determine whether microbial-associated molecular pattern-triggered gene expression involves modifications at the chromatin level.Histone acetylation and deacetylation are major regulators of microbial-associated molecular pattern-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defence gene expression and innate immunity. The MAP kinase MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase.By studying a number of gene loci that undergo microbial-associated molecular pattern-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.

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UR - https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1261-8

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U2 - 10.1186/s13059-017-1261-8

DO - 10.1186/s13059-017-1261-8

M3 - Article

C2 - 28683804

SN - 1474-760X

VL - 18

JO - Genome biology

JF - Genome biology

IS - 1

ER -

MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity

Abstract

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