Manganese Catalyzed Regioselective C–H Alkylation: Experiment and Computation

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A new efficient manganese-catalyzed selective C2-alkylation of indoles via carbenoid insertion has been achieved. The newly developed C-H functionalization protocol provides access to diverse products and shows good functional group tolerance. Mechanistic and computational studies support the formation of a Mn(CO)3 acetate complex as the catalytically active species.
Original languageEnglish (US)
Pages (from-to)3105-3108
Number of pages4
JournalOrganic Letters
Issue number10
StatePublished - May 8 2018

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: B.M. and L.C. acknowledge King Abdullah University of Science and Technology (KAUST) for support and the KAUST Supercomputing Laboratory for providing computational resources of the supercomputer Shaheen II


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